Vitamin K-dependent proteins in patients undergoing head and neck free flap surgery - a prospective observational study.

IF 1.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Scandinavian Journal of Clinical & Laboratory Investigation Pub Date : 2026-01-01 Epub Date: 2026-06-27 DOI:10.1080/00365513.2026.2694050

Karolina Persson, Caroline Ulfsdotter Nilsson, Johanna Sjövall, Louise Walther Sturesson, Leon Schurgers, Thomas Kander

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引用次数: 0

Abstract

Background/objectives: Vitamin K dependent proteins are involved in numerous biological processes, including coagulation, cancer development and inflammation, but their profile and functions in many patient groups and conditions are still unknown. The aim of this study was to describe vitamin K dependent proteins in patients undergoing head and neck free flap surgery, with the hypothesis that these patients experience postoperative vitamin K deficiency.

Methods: A prospective observational study including 39 patients undergoing extensive head and neck resection and reconstruction using free flap(s) was conducted with analyses of the γ-carboxyglutamic acid-containing proteins desphospho-uncarboxylated Matrix Gla Protein (dp-uc-MGP), Growth arrest-specific gene 6 (Gas6) and Protein Induced by Vitamin K Absence/Antagonist for FII (PIVKA-II), as well as soluble Axl receptor (sAxl), on the day of surgery and postoperative (POD) days 1, 2 and 6. Changes from preoperative levels were explored using Kruskal-Wallis test with a Dunn's post hoc multiple comparison's test.

Results: Gas6 showed a significant increase from preoperative levels to all postoperative days (POD1 and 2 p < 0.001, POD6 p = 0.002). For PIVKA-II a continuous increase was seen throughout the study period (POD1 ns, POD2 and 6 p < 0.001). No significant changes were seen in dp-uc-MGP or sAxl levels.

Conclusions: Patients undergoing head and neck free flap surgery show signs of vitamin K deficiency during the first postoperative week.

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头颈部游离皮瓣手术患者的维生素k依赖蛋白-一项前瞻性观察研究。

背景/目的：维生素K依赖蛋白参与许多生物过程，包括凝血、癌症发展和炎症，但它们在许多患者群体和条件下的特征和功能仍然未知。本研究的目的是描述头颈部游离皮瓣手术患者的维生素K依赖蛋白，假设这些患者术后维生素K缺乏。方法：对39例接受大范围头颈部切除术和游离皮瓣重建的患者进行前瞻性观察研究，分析手术当天和术后（POD）第1、2和6天含γ-羧谷氨酸蛋白去磷-无羧化基质玻璃蛋白（dp- ucm - mgp）、生长抑制特异性基因6 （Gas6）和维生素K缺失/ FII拮抗剂诱导蛋白（PIVKA-II）以及可溶性Axl受体（sAxl）。使用Kruskal-Wallis试验和Dunn事后多重比较试验探讨术前水平的变化。结果：Gas6从术前水平到术后各天均有显著升高（POD1和2 p = 0.002）。在整个研究期间，PIVKA-II持续增加（POD1 ns， POD2和6p）。结论：接受头颈部游离皮瓣手术的患者在术后第一周出现维生素K缺乏的迹象。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scandinavian Journal of Clinical & Laboratory Investigation 医学-医学：研究与实验

CiteScore

3.50

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： The Scandinavian Journal of Clinical and Laboratory Investigation is an international scientific journal covering clinically oriented biochemical and physiological research. Since the launch of the journal in 1949, it has been a forum for international laboratory medicine, closely related to, and edited by, The Scandinavian Society for Clinical Chemistry. The journal contains peer-reviewed articles, editorials, invited reviews, and short technical notes, as well as several supplements each year. Supplements consist of monographs, and symposium and congress reports covering subjects within clinical chemistry and clinical physiology.