Cell surface Glycans: from recognition technologies and functional editing to medical applications.

IF 3.3 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Glycobiology Pub Date : 2026-05-22 DOI:10.1093/glycob/cwag050

Tingting Zhang, Yongbin Xu, Yupeng Liu, Lingyan Zhu, Jie Chen, Shunchun Wang, Huijun Wang

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引用次数: 0

Abstract

Cell-surface glycans play essential roles in cell communication, immune recognition, and disease progression. Their medical applications are supported by two important technological pillars: glycan recognition and glycan editing. This Review focuses on three key directions: recognition technologies, namely, in situ imaging and glycomic profiling, for detecting and profiling glycans; functional editing technologies, including genetic, enzymatic, chemical, and metabolic approaches, for precisely remodelling glycans; and medical applications driven by the synergy between recognition and editing, with a focus on four areas: biomarkers, lectin-based therapies, precision glycan editing, and cancer immunotherapy. Throughout the Review, five representative glycan classes-high-mannose N-glycans, mucin-type O-GalNAc, heparan sulfate, ganglioside GM3, and glycoRNAs-are used as recurring examples wherever possible. This Review offers an integrated perspective to navigate the process by which glycan recognition and editing technologies collectively drive the translation of cell-surface glycan research into clinical practice.

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细胞表面聚糖：从识别技术和功能编辑到医学应用。

细胞表面聚糖在细胞通讯、免疫识别和疾病进展中发挥重要作用。它们的医学应用得到了两个重要技术支柱的支持：聚糖识别和聚糖编辑。本文综述了三个关键方向：识别技术，即原位成像和糖糖谱分析，用于检测和分析聚糖；功能编辑技术，包括基因、酶、化学和代谢方法，用于精确重塑聚糖；以及由识别和编辑之间的协同作用驱动的医学应用，重点关注四个领域：生物标志物、基于凝集素的疗法、精确聚糖编辑和癌症免疫治疗。在整个综述中，五种具有代表性的聚糖类——高甘露糖n-聚糖、粘蛋白型O-GalNAc、硫酸肝素、神经节苷脂GM3和glycorna——被尽可能地作为反复出现的例子。这篇综述提供了一个综合的视角来引导聚糖识别和编辑技术共同推动细胞表面聚糖研究转化为临床实践的过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Glycobiology 生物-生化与分子生物学

CiteScore

7.50

自引率

4.70%

发文量

审稿时长

3 months

期刊介绍： Established as the leading journal in the field, Glycobiology provides a unique forum dedicated to research into the biological functions of glycans, including glycoproteins, glycolipids, proteoglycans and free oligosaccharides, and on proteins that specifically interact with glycans (including lectins, glycosyltransferases, and glycosidases). Glycobiology is essential reading for researchers in biomedicine, basic science, and the biotechnology industries. By providing a single forum, the journal aims to improve communication between glycobiologists working in different disciplines and to increase the overall visibility of the field.