The correlation of CRP/Alb ratio with low muscle mass in patients with type 2 diabetes mellitus: a cross-sectional research.

IF 3.7 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

BMC Endocrine Disorders Pub Date : 2026-06-26 DOI:10.1186/s12902-026-02392-x

Rui Wang, Wenchao Hu, Guotao Liu, Zheng Mou

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引用次数: 0

Abstract

Background: Sarcopenia is a prominent age-related condition with low muscle mass, yet its underlying pathogenesis remains unclear. Type 2 diabetes mellitus (T2DM) is a well-recognized risk factor for this disorder. Recent data indicates that low muscle mass or sarcopenia is closely linked to high C-reactive protein-to-albumin (CRP/Alb) ratio in patients with esophageal, gastric and colorectal cancers.

Methods: Therefore, this study aimed to investigate the association between the CRP/Alb ratio and low muscle mass in a T2DM population. This study included 1009 participants (549 males and 460 females) diagnosed with T2DM. Dual energy X-ray absorptiometry was utilized to measure the skeletal muscle index (SMI). Low muscle mass was identified based on the diagnostic criteria established by the Asian Working Group for Sarcopenia (AWGS).

Results: Our findings revealed that low muscle mass was present in 110 male patients (20.04%) and 62 female patients (13.48%). In univariate logistic regression analysis, the C-reactive protein -to-Albumin ratio (CRP/Alb) was significantly associated with low muscle mass in men with T2DM (Odds Ratio (OR) = 1.084 [95%CI = 1.014 ~ 1.158], p = 0.017). The association remained significant after adjusting for age, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), diastolic blood pressure (DBP) and body mass index (BMI) in the multiple logistic regression model (OR = 1.142 [95%CI = 1.028 ~ 1.269], p = 0.013). No significant association between CRP/Alb ratio and the risk of low muscle mass was observed in the female participants (OR = 0.975 [95%CI = 0.868 ~ 1.095], p = 0.672). In multiple linear regression analyses, SMI was positively associated with Alb, BMI, total cholesterol (TC) and HbA1c in males, but negatively related to associated with age. In females, SMI was positively associated with BMI and smoking duration.

Conclusion: The CRP/Alb ratio was positively related to low muscle mass in men with T2DM.

Clinical trial number: Not applicable.

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2型糖尿病患者CRP/Alb比值与低肌肉质量的相关性：一项横断面研究

背景：肌肉减少症是一种显著的与年龄相关的低肌肉量疾病，但其潜在的发病机制尚不清楚。2型糖尿病（T2DM）是该疾病公认的危险因素。最近的数据表明，食管癌、胃癌和结直肠癌患者的低肌肉量或肌肉减少与高c反应蛋白/白蛋白（CRP/Alb）比率密切相关。方法：因此，本研究旨在探讨2型糖尿病人群中CRP/Alb比值与低肌肉质量之间的关系。该研究包括1009名诊断为T2DM的参与者（549名男性和460名女性）。采用双能x线骨骼肌指数（SMI）测定。低肌肉量是根据亚洲肌肉减少症工作组（AWGS）制定的诊断标准确定的。结果：男性110例（20.04%），女性62例（13.48%）存在低肌肉量。单因素logistic回归分析显示，2型糖尿病患者c反应蛋白/白蛋白比（CRP/Alb）与低肌肉质量显著相关（比值比(OR) = 1.084 [95%CI = 1.014 ~ 1.158], p = 0.017）。在多元logistic回归模型中调整年龄、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、舒张压（DBP）和体重指数（BMI）后，相关性仍然显著（OR = 1.142 [95%CI = 1.028 ~ 1.269], p = 0.013）。在女性受试者中，CRP/Alb比值与低肌肉质量风险无显著相关性（OR = 0.975 [95%CI = 0.868 ~ 1.095], p = 0.672）。多元线性回归分析显示，男性SMI与Alb、BMI、总胆固醇（TC）、HbA1c呈正相关，与年龄呈负相关。在女性中，重度精神障碍与BMI和吸烟时间呈正相关。结论：2型糖尿病患者CRP/Alb比值与低肌量呈正相关。临床试验号：不适用。

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来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.