Does early surgical intervention for type II dens fractures improve survival in octogenarians? A propensity-matched analysis.

IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY
Ziam Khan, Kevin T Kim, Parantap Patel, Timothy Chryssikos
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引用次数: 0

Abstract

Study design: Retrospective Cohort Study.

Objectives: To compare mortality and downstream morbidity after early operative versus nonoperative management of isolated Type II dens fractures in octogenarians.

Methods: TriNetX was queried to identify patients aged 80 years and older with a new diagnosis of Type II dens fracture. Patients with spinal cord injury, traumatic brain injury, or other major traumatic injuries were excluded. Patients were stratified by early operative intervention, defined as surgical fixation within 14 days, versus nonoperative management, defined as no surgical fixation after diagnosis. The primary outcome was mortality. Propensity score matching was performed 1:1 using demographic and clinical variables. Mortality was assessed at 9 months, 1 year, 2 years, and 3 years. Secondary outcomes included hospital readmission and long-term post-injury opioid use between 6 months and 3 years.

Results: After matching, 156 patients were included in each cohort. No significant differences in mortality were observed between cohorts at 9 months, 1 year, 2 years, or 3 years. Early operative intervention was associated with lower 90-day readmission (7.1% vs 17.9%; OR 0.35, 95% CI 0.17-0.73; p = 0.0036), lower 6-month readmission (9.0% vs 21.2%; OR 0.37, 95% CI 0.19-0.72; p = 0.0026), and lower long-term post-injury opioid use (16.0% vs 26.9%; OR 0.52, 95% CI 0.30-0.90; p = 0.0191).

Conclusions: In octogenarians with isolated Type II dens fractures, early surgery was not associated with improved long-term mortality, but was associated with lower readmission and reduced long-term post-injury opioid use.

早期手术干预II型牙髓骨折能提高80多岁老人的生存率吗?倾向匹配分析。
研究设计:回顾性队列研究。目的:比较八旬老人孤立型ⅱ型牙突骨折早期手术与非手术治疗后的死亡率和下游发病率。方法:对TriNetX进行查询,确定80岁及以上新诊断为II型牙槽骨骨折的患者。排除脊髓损伤、创伤性脑损伤或其他重大创伤性损伤患者。根据早期手术干预(定义为14天内手术固定)和非手术治疗(定义为诊断后不手术固定)对患者进行分层。主要结局是死亡率。使用人口统计学和临床变量进行1:1的倾向评分匹配。分别在9个月、1年、2年和3年评估死亡率。次要结局包括再入院和伤后阿片类药物长期使用6个月至3年。结果:匹配后,每个队列纳入156例患者。在9个月、1年、2年或3年时,各组之间的死亡率没有显著差异。早期手术干预与较低的90天再入院率(7.1% vs 17.9%; OR 0.35, 95% CI 0.17-0.73; p = 0.0036)、较低的6个月再入院率(9.0% vs 21.2%; OR 0.37, 95% CI 0.19-0.72; p = 0.0026)以及较低的伤后长期阿片类药物使用率(16.0% vs 26.9%; OR 0.52, 95% CI 0.30-0.90; p = 0.0191)相关。结论:在80多岁的孤立型II齿状骨折患者中,早期手术与改善长期死亡率无关,但与较低的再入院率和减少长期损伤后阿片类药物使用有关。
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来源期刊
British Journal of Neurosurgery
British Journal of Neurosurgery 医学-临床神经学
CiteScore
2.30
自引率
9.10%
发文量
139
审稿时长
3-8 weeks
期刊介绍: The British Journal of Neurosurgery is a leading international forum for debate in the field of neurosurgery, publishing original peer-reviewed articles of the highest quality, along with comment and correspondence on all topics of current interest to neurosurgeons worldwide. Coverage includes all aspects of case assessment and surgical practice, as well as wide-ranging research, with an emphasis on clinical rather than experimental material. Special emphasis is placed on postgraduate education with review articles on basic neurosciences and on the theory behind advances in techniques, investigation and clinical management. All papers are submitted to rigorous and independent peer-review, ensuring the journal’s wide citation and its appearance in the major abstracting and indexing services.
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