Overcoming conformational strain in directed C3-C(sp3)–H activation for saturated azacycles

IF 48.3 1区化学 Q1 CHEMISTRY, PHYSICAL

Nature Catalysis Pub Date : 2026-06-09 DOI:10.1038/s41929-026-01549-0

引用次数: 0

Abstract

Functionalization of saturated azacycles through Pd-catalysed C3-C(sp3)–H activation leveraging the endocyclic nitrogen as a directing group has been hindered by the intrinsic geometric strain of the palladacycle intermediate. Now, an amine N-oxide strategy overcomes this issue by forming a favourable five-membered palladacycle transition state, enabling selective C3 arylation.

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饱和氮杂环定向C3-C(sp3) -H活化中克服构象应变

利用内环氮作为导向基团通过pd催化的C3-C(sp3) -H活化饱和氮杂环的功能化受到钯环中间体固有几何应变的阻碍。现在，胺n -氧化物策略通过形成有利的五元泛环过渡态克服了这一问题，从而实现了选择性的C3芳基化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Catalysis Chemical Engineering-Bioengineering

CiteScore

52.10

自引率

1.10%

发文量

140

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