Mitochondria–endoplasmic reticulum contact sites as hubs where mitochondria acquire iron

IF 22.7 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2026-06-26 DOI:10.1038/s41556-026-02008-5

引用次数: 0

Abstract

The exact routes and mechanisms of iron acquisition by mitochondria are unclear. We identify mitochondria–endoplasmic reticulum contact sites as an iron supply hub and reveal that the mitochondrial ubiquitin ligase MITOL regulates HMOX2 activity, to enable delivery of haem-derived iron to sustain mitochondrial iron homeostasis.

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线粒体-内质网接触点是线粒体获取铁的枢纽。

线粒体获取铁的确切途径和机制尚不清楚。我们确定线粒体-内质网接触位点是铁供应中心，并揭示线粒体泛素连接酶MITOL调节HMOX2活性，使血源性铁的输送能够维持线粒体铁的稳态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology