Associations of metabolic heterogeneity of obesity with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH): longitudinal cohort and cross-sectional study.

IF 3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2026-12-31 Epub Date: 2026-06-26 DOI:10.1080/13685538.2026.2685423

Qingze Xiao, Wei Xiao

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引用次数: 0

Abstract

Background: Based on data from the China Health and Retirement Longitudinal Study (CHARLS) and a Hunan cross-sectional study, the study investigated the link between metabolic heterogeneity of obesity (MHO) and lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH).

Methods: The cohort study included 2278 males, and the cross-sectional study included 851 males; all were divided into four BMI-metabolic categories: MHNW, MUNW, MHOO, and MUOO.

Results: This cross-sectional study found LUTS/BPH patients were younger, more urban-dwelling, with higher education and MHOO/MUOO prevalence. Both studies showed age, residence, education, obesity, and metabolic heterogeneity were linked with LUTS/BPH; CHARLS also linked arthritis and liver illness to LUTS/BPH.

Conclusions: Logistic regression showed unadjusted associations for MHOO (OR = 1.84, 95% CI: 1.22-2.78, p = 0.0038) and MUOO (OR = 1.59, 95% CI: 1.15-2.19, p = 0.0051), but only MHOO remained significant after adjusting for age and multiple factors, indicating that it was independently associated with LUTS/BPH regardless of confounders.

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肥胖代谢异质性与提示良性前列腺增生（LUTS/BPH）的下尿路症状的关联：纵向队列和横断面研究

背景：基于中国健康与退休纵向研究（CHARLS）和湖南横断面研究的数据，本研究探讨了肥胖（MHO）代谢异质性与良性前列腺增生（LUTS/BPH）相关下尿路症状之间的关系。方法：队列研究纳入2278名男性，横断面研究纳入851名男性；所有人都被分为四个bmi代谢类别：MHNW， MUNW， MHOO和MUOO。结果：这项横断面研究发现LUTS/BPH患者更年轻，更多地居住在城市，具有高等教育和MHOO/ muo患病率。两项研究均表明，年龄、居住地、教育程度、肥胖和代谢异质性与LUTS/BPH相关；CHARLS还将关节炎和肝脏疾病与LUTS/BPH联系起来。结论：Logistic回归显示MHOO （OR = 1.84, 95% CI: 1.22-2.78, p = 0.0038）和MUOO （OR = 1.59, 95% CI: 1.15-2.19, p = 0.0051）存在未调整的相关性，但在调整年龄和多因素后，只有MHOO仍具有显著性，表明无论混杂因素如何，MHOO与LUTS/BPH独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.