Jing Xu, Lianjun Chen, Huyan Chen, Shangshang Wang
{"title":"Nonfamilial Unilateral Linear Eccrine Syringofibroadenoma of the Plantar Surface: A Diagnostic Consideration in Acral Eccrine Proliferations.","authors":"Jing Xu, Lianjun Chen, Huyan Chen, Shangshang Wang","doi":"10.1097/DAD.0000000000003329","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Eccrine syringofibroadenoma (ESFA) is an uncommon benign adnexal neoplasm characterized by eccrine ductal differentiation and a distinctive reticulated architectural pattern. The nonfamilial unilateral linear subtype is exceedingly rare and may pose diagnostic difficulty, particularly in acral locations. We describe a long-standing unilateral linear plantar lesion in a middle-aged woman. Histopathological examination revealed anastomosing epithelial cords extending from the epidermis into a fibrovascular stroma, with associated eccrine duct-like structures, consistent with ESFA. Recognition of these characteristic features is essential to distinguish ESFA from other reactive, infectious, and neoplastic eccrine proliferations encountered in dermatopathology practice.</p>","PeriodicalId":50967,"journal":{"name":"American Journal of Dermatopathology","volume":" ","pages":"717-719"},"PeriodicalIF":0.8000,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Dermatopathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/DAD.0000000000003329","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/5/27 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract: Eccrine syringofibroadenoma (ESFA) is an uncommon benign adnexal neoplasm characterized by eccrine ductal differentiation and a distinctive reticulated architectural pattern. The nonfamilial unilateral linear subtype is exceedingly rare and may pose diagnostic difficulty, particularly in acral locations. We describe a long-standing unilateral linear plantar lesion in a middle-aged woman. Histopathological examination revealed anastomosing epithelial cords extending from the epidermis into a fibrovascular stroma, with associated eccrine duct-like structures, consistent with ESFA. Recognition of these characteristic features is essential to distinguish ESFA from other reactive, infectious, and neoplastic eccrine proliferations encountered in dermatopathology practice.
期刊介绍:
The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports.
With the The American Journal of Dermatopathology you''ll be able to:
-Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies.
-Apply the latest basic science findings and clinical approaches to your work right away.
-Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations.
-Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians