Beyond estrobolome 1.0: unraveling endocrine-microbiome axis as a driver and therapeutic target in hormone-driven cancers.

IF 11.4 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2026-06-24 DOI:10.1038/s41522-026-01074-9

Exian Mou, Rui Guo, Yong Yi, Yang Li, Yutang Yao, Jia Xu

引用次数: 0

Abstract

The endocrine-microbiome axis extends the estrobolome concept, recognizing gut microbes as active endocrine partners. Bacteria modulate estrogen recycling via diverse enzymes and produce SERM-like metabolites, while host hormones shape microbial communities. This bidirectional crosstalk influences hormone-driven carcinogenesis through inflammation, genomic instability, and epigenetic changes. Therapeutic opportunities include precision probiotics and selective enzymatic inhibition. Advancing the field requires causal models, multi-omics integration, and sex as a biological variable.

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超越雌激素1.0：解开内分泌-微生物轴作为激素驱动型癌症的驱动和治疗靶点。

内分泌-微生物组轴扩展了雌激素的概念，认识到肠道微生物是积极的内分泌伙伴。细菌通过多种酶调节雌激素循环并产生类似serm的代谢物，而宿主激素则塑造微生物群落。这种双向串扰通过炎症、基因组不稳定和表观遗传变化影响激素驱动的致癌作用。治疗机会包括精密益生菌和选择性酶抑制。推进这一领域需要因果模型、多组学整合和性别作为一个生物学变量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.