Research Progress on Biomaterial Scaffolds Carrying Stem Cells for Inflammation Regulation After Spinal Cord Injury.

IF 4.9 3区医学 Q2 CELL & TISSUE ENGINEERING

Stem Cell Reviews and Reports Pub Date : 2026-10-01 Epub Date: 2026-06-23 DOI:10.1007/s12015-026-11182-w

Nanjian Xu, Xiaoyin Chai, Weihu Ma, Weihu Zhang, Fang Yang

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引用次数: 0

Abstract

The inflammatory cascade triggered by spinal cord injury (SCI) presents a major barrier to tissue repair. This review summarizes recent advances in this field. It outlines the selection criteria for different scaffold materials and stem cells. It also describes key strategies for the coordinated regulation of the inflammatory microenvironment, including structural support and immunomodulation. In addition, the review discusses cell-free therapies and the functionalization of stem cell-derived materials. Intelligent responsive systems are also highlighted. Furthermore, this article evaluates the validation of these approaches in preclinical models. It also examines the challenges associated with their clinical translation. Finally, emerging trends, including dynamic adaptation, functional integration, and precise regeneration, are discussed. This review aims to provide a theoretical foundation and to guide future research on combination therapies for SCI.

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携带干细胞的生物材料支架用于脊髓损伤后炎症调节的研究进展。

由脊髓损伤（SCI）引发的炎症级联反应是组织修复的主要障碍。本文综述了该领域的最新进展。它概述了不同支架材料和干细胞的选择标准。它还描述了炎症微环境协调调节的关键策略，包括结构支持和免疫调节。此外，本文还讨论了无细胞治疗和干细胞衍生材料的功能化。智能响应系统也被强调。此外，本文评估了这些方法在临床前模型中的有效性。它还检查了与他们的临床翻译相关的挑战。最后，讨论了动态适应、功能整合和精确再生等新兴趋势。本文综述旨在为今后脊髓损伤联合治疗的研究提供理论基础和指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cell Reviews and Reports 医学-细胞生物学

CiteScore

9.30

自引率

4.20%

发文量

审稿时长

3 months

期刊介绍： The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.