Oxygen homeostasis: new insight of gut microbiota-host interactions.

IF 11.4 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2026-06-23 DOI:10.1038/s41522-026-01062-z

Zhipeng Yang, Juan Yang, Jian Peng, Hongkui Wei

引用次数: 0

Abstract

Oxygen homeostasis is a key ecological factor shaping microbial composition, epithelial function, and immune balance in the gut. Spatial and developmental oxygen gradients drive the transition from facultative to obligate anaerobes. Gut hypoxia is maintained by epithelial oxygen consumption and microbial metabolism, forming a positive feedback loop that supports barrier integrity and immune homeostasis. Disruption by inflammation, antibiotics, or diet elevates oxygen availability, promoting dysbiosis, pathogen expansion, and disease risk.

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氧稳态：肠道微生物-宿主相互作用的新见解。

氧稳态是影响肠道微生物组成、上皮功能和免疫平衡的关键生态因素。空间和发育氧梯度驱动兼性厌氧向专性厌氧的转变。肠道缺氧由上皮氧气消耗和微生物代谢维持，形成一个支持屏障完整性和免疫稳态的正反馈循环。炎症、抗生素或饮食引起的破坏会提高氧气的可用性，促进生态失调、病原体扩张和疾病风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.