Prevalence and Predictors of Cancer-Related Fatigue in Breast Cancer-Related Lymphedema Patients: A Cross-Sectional Study.

IF 1.7 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Lymphatic research and biology Pub Date : 2026-06-23 DOI:10.1177/15578585261461399

Yanfei Liu, Luxin Wang, Xincan Zhou, Zhiyue Li, Xiao Ruan, Han Su, Weihong Zhang, Fangyuan Liu

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引用次数: 0

Abstract

Purpose: Cancer-related fatigue (CRF) is the most common symptom of cancer patients. This study aimed to investigate the prevalence of CRF among patients with breast cancer-related lymphedema (BCRL) and to indentify the factors associated with its occurrence.

Methods: In this cross-sectional study, women with BCRL (N = 260) were recruited from the three general hospitals. Lymphedema status was determined using the Norman telephone questionnaire as the patient-reported occurrence of hand/lower arm/upper arm swelling. CRF status was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire. Multiple binary logistic regression analysis was used to identify factors associated with CRF.

Results: The median time from BC diagnosis was 29 months (interquartile range, 15.0-62.0 months). The prevalence of CRF among BCRL patients was 88.46%. The median sedentary time was 245 min/day (IQR: 150-330min/day), and 34.23% of the patients did not meet the moderate-intensity physical activity level. Abnormal postoperative wound healing status, radiotherapy, hormonal therapy, lymphedema severity and failure to meet moderate-intensity physical activity level were associated with an increased risk of CRF.

Conclusion: CRF is highly prevalent among patients with BCRL. Targeted interventions aimed at promoting moderate-intensity physical activity and improving long-term symptom management may help alleviate fatigue.

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乳腺癌相关淋巴水肿患者癌症相关疲劳的患病率和预测因素：一项横断面研究

目的：癌症相关性疲劳（cancer -related fatigue， CRF）是癌症患者最常见的症状。本研究旨在调查乳腺癌相关性淋巴水肿（BCRL）患者中CRF的患病率，并确定其发生的相关因素。方法：在本横断面研究中，从三家综合医院招募患有BCRL的妇女（N = 260）。淋巴水肿状况采用Norman电话问卷作为患者报告的手/下臂/上臂肿胀的发生情况。使用慢性疾病治疗功能评估-疲劳问卷评估CRF状态。采用多元二元logistic回归分析确定与CRF相关的因素。结果：BC诊断的中位时间为29个月（四分位数范围为15.0-62.0个月）。BCRL患者中CRF患病率为88.46%。中位久坐时间为245分钟/天（IQR: 150-330分钟/天），34.23%的患者未达到中等强度体力活动水平。术后伤口愈合状态异常、放疗、激素治疗、淋巴水肿严重程度和未达到中等强度体力活动水平与CRF风险增加相关。结论：CRF在BCRL患者中高发。有针对性的干预措施旨在促进中等强度的身体活动和改善长期症状管理可能有助于缓解疲劳。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lymphatic research and biology Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.10

自引率

7.10%

发文量

审稿时长

>12 weeks

期刊介绍： Lymphatic Research and Biology delivers the most current peer-reviewed advances and developments in lymphatic biology and pathology from the world’s leading biomedical investigators. The Journal provides original research from a broad range of investigative disciplines, including genetics, biochemistry and biophysics, cellular and molecular biology, physiology and pharmacology, anatomy, developmental biology, and pathology. Lymphatic Research and Biology coverage includes: -Vasculogenesis and angiogenesis -Genetics of lymphatic disorders -Human lymphatic disease, including lymphatic insufficiency and associated vascular anomalies -Physiology of intestinal fluid and protein balance -Immunosurveillance and immune cell trafficking -Tumor biology and metastasis -Pharmacology -Lymphatic imaging -Endothelial and smooth muscle cell biology -Inflammation, infection, and autoimmune disease