Pellegrino Cerino, Antonio Pizzolante, Carlo Buonerba, Paolo Montuori
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引用次数: 0
Abstract
Background and objectives: We characterized fine-scale geographic variation in serum trace metals across Campania (southern Italy).
Materials and methods: In 2016-2017, the SPES programme sampled residents aged 20-49 years from municipal registries across Campania. Municipalities were stratified using an environmental-pressure index into three broad impact strata: high-impact, medium-impact and low-impact. For higher spatial resolution, municipalities were also grouped into 21 predefined municipal clusters. We measured 20 serum trace metals by ICP-MS and estimated age- and sex-adjusted geometric mean ratios (GMRs) comparing each stratum or cluster with the study-wide geometric mean.
Results: Of 4205 enrolled participants, 4188 were included. Medium-impact areas showed higher mercury (GMR 1.87, 95% CI 1.73-2.02) and antimony (1.95, 1.71-2.23) relative to the cohort average. At the municipal-cluster scale, the Irno Valley clusters around the Fonderie Pisano foundry (Baronissi-Pellezzano and Salerno) had about six-fold higher mercury (GMR 5.71 and 6.10) and about three-fold higher antimony (3.45 and 2.93), whereas the Valle del Sabato cluster showed about ten-fold higher antimony (GMR 10.5) and about seven-fold higher nickel (7.16) and cadmium (7.67).
Conclusions: Overall serum metal concentrations were broadly comparable with European general-population ranges, but pronounced small-area heterogeneity indicates localized hotspots that provincial or regional averages can obscure.
背景和目的：我们描述了坎帕尼亚（意大利南部）地区血清微量金属的精细地理差异。材料和方法：2016-2017年，SPES项目从坎帕尼亚的市政登记处抽取了20-49岁的居民样本。使用环境压力指数将城市划分为三个广泛的影响阶层：高影响、中等影响和低影响。为了获得更高的空间分辨率，还将城市划分为21个预定义的城市集群。我们用ICP-MS测量了20种血清微量金属，并估计了年龄和性别调整后的几何平均比率（GMRs），将每个阶层或群体与研究范围内的几何平均进行比较。结果：在4205名入组参与者中，有4188人被纳入。中等影响地区的汞（GMR 1.87, 95% CI 1.73-2.02）和锑（1.95,1.71-2.23）相对于队列平均值较高。在城市集群规模上，围绕Fonderie Pisano铸造厂（baronisi - pellezzano和Salerno）的Irno山谷集群的汞（GMR为5.71和6.10）高出约6倍，锑（GMR为3.45和2.93）高出约3倍，而Valle del Sabato集群的锑（GMR为10.5）高出约10倍，镍（7.16）和镉（7.67）高出约7倍。结论：总体血清金属浓度与欧洲一般人群范围大致相当，但明显的小区域异质性表明局部热点，省或地区平均值可能掩盖。
期刊介绍：
Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries
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