Comparison of the effectiveness of 30% Aloe vera cream and 20% urea cream as topical treatment for xerosis cutis in chronic kidney disease: a randomized clinical trial.

IF 1 Q2 DERMATOLOGY

Dermatology Reports Pub Date : 2026-06-24 DOI:10.4081/dr.2026.10496

Nur Hikmah Fajriani, Khairuddin Djawad, Farida Tabri, Andi Alfian Zainuddin, Haerani Rasyid, Widya Widita

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Abstract

Xerosis is a prevalent skin disorder among patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). While both Aloe vera cream 30% and urea cream 20% have been shown to improve skin hydration in cases of xerosis cutis, direct comparisons between the two are limited. This study aims to compare the effectiveness of both creams in treating xerosis cutis in patients with chronic kidney disease on hemodialysis (CKD-HD). A randomized controlled trial was conducted involving 35 eligible CKD-HD patients. Each patient received either urea cream 20% or A. vera cream 30%, which was applied to both their left and right arms. Skin moisture was assessed weekly using corneometer readings and overall dry skin (ODS) scores over 4 weeks. The present study reveals that both treatments significantly increased corneometer readings and decreased ODS scores compared to baseline (p<0.05), but no significant difference was found between the two creams (p>0.05). In conclusion, A. vera cream 30% and urea cream 20% demonstrate similar effectiveness in improving skin moisture for patients with xerosis cutis associated with CKD-HD.

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30%芦荟乳膏和20%尿素乳膏局部治疗慢性肾病皮肤干燥症的疗效比较：一项随机临床试验。

干枯症是慢性肾病（CKD）患者接受血液透析（HD）时常见的皮肤病。虽然30%的芦荟霜和20%的尿素霜都被证明可以改善皮肤干燥症的水分，但两者之间的直接比较是有限的。本研究旨在比较两种药膏治疗慢性肾脏疾病血液透析（CKD-HD）患者皮肤干燥症的疗效。一项随机对照试验纳入35例符合条件的CKD-HD患者。每位患者分别使用20%尿素乳膏或30%芦荟乳膏，分别涂抹于左、右臂。在4周的时间里，每周使用角膜测量仪读数和总体皮肤干燥（ODS）评分评估皮肤水分。本研究显示，与基线相比，两种治疗方法均显著提高了角质计读数并降低了ODS评分（p0.05）。综上所述，30%芦荟乳膏和20%尿素乳膏在改善CKD-HD相关皮肤干燥症患者皮肤水分方面表现出相似的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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