{"title":"A novel hypothesis for stroke prediction, introducing CHA<sub>2</sub>DS<sub>2</sub>-VAScF.","authors":"Ahmed B Shamsulddin","doi":"10.1080/03007995.2026.2692164","DOIUrl":null,"url":null,"abstract":"<p><p>Preventing strokes in patients with atrial fibrillation (AF) is one of the most critical daily tasks facing clinicians in cardiovascular medicine. Yet, our primary tool-the CHA<sub>2</sub>DS<sub>2</sub>-VASc score-frequently misses the mark because it completely ignores heritable risk. While we have landmark evidence showing that a family history of stroke is a powerful, independent risk factor, we still lack a practical way to use this information in daily practice. This gap between evidence and daily practice leaves vulnerable patients unprotected. In this commentary, we hypothesize: the CHA<sub>2</sub>DS<sub>2</sub>-VAScF score, which adds a single point for a positive family history of thrombotic events (ischemic stroke, heart attack, or blood clots). By translating established genetic risk into a practical bedside tool, CHA<sub>2</sub>DS<sub>2</sub>-VAScF can help us identify high-risk patients who currently slip through the cracks-especially those with \"borderline\" scores who might otherwise be denied life-saving therapy.</p>","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":" ","pages":"873-877"},"PeriodicalIF":2.8000,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Medical Research and Opinion","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/03007995.2026.2692164","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/24 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
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Abstract
Preventing strokes in patients with atrial fibrillation (AF) is one of the most critical daily tasks facing clinicians in cardiovascular medicine. Yet, our primary tool-the CHA2DS2-VASc score-frequently misses the mark because it completely ignores heritable risk. While we have landmark evidence showing that a family history of stroke is a powerful, independent risk factor, we still lack a practical way to use this information in daily practice. This gap between evidence and daily practice leaves vulnerable patients unprotected. In this commentary, we hypothesize: the CHA2DS2-VAScF score, which adds a single point for a positive family history of thrombotic events (ischemic stroke, heart attack, or blood clots). By translating established genetic risk into a practical bedside tool, CHA2DS2-VAScF can help us identify high-risk patients who currently slip through the cracks-especially those with "borderline" scores who might otherwise be denied life-saving therapy.
期刊介绍：
Current Medical Research and Opinion is a MEDLINE-indexed, peer-reviewed, international journal for the rapid publication of original research on new and existing drugs and therapies, Phase II-IV studies, and post-marketing investigations. Equivalence, safety and efficacy/effectiveness studies are especially encouraged. Preclinical, Phase I, pharmacoeconomic, outcomes and quality of life studies may also be considered if there is clear clinical relevance
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