Primary Orbital Extranodal NK/T-Cell Lymphoma: A European Case Report.

IF 0.6 Q4 OPHTHALMOLOGY

Case Reports in Ophthalmology Pub Date : 2026-05-18 eCollection Date: 2026-01-01 DOI:10.1159/000551675

Alexander L Rattunde, Lukas M Möhwald, Catarina A Kunze, Simon Schallenberg, Eckart Bertelmann

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引用次数: 0

Abstract

Introduction: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL), is a rare and aggressive malignancy. Primary orbital involvement is exceptionally uncommon. We report a case of orbital ENKTL in a White patient presenting with rapidly progressive orbital symptoms.

Case presentation: A 69-year-old woman presented with eyelid swelling, diplopia, and exophthalmos. An initial diagnosis of conjunctivitis by a community ophthalmologist proved unresponsive to treatment, prompting referral to a tertiary eye center. Orbital magnetic resonance imaging revealed a retrobulbar mass. Biopsy confirmed Epstein-Barr virus-associated ENKTL, and staging excluded systemic disease. The patient received age-adjusted modified SMILE (mSMILE) chemotherapy (dexamethasone, methotrexate, ifosfamide, l-asparaginase, etoposide) followed by concurrent platinum-based chemoradiotherapy. She achieved complete remission and reported substantial improvement in quality of life.

Conclusions: Even exceptionally rare orbital lesions should be considered in cases of rapidly progressive orbital disease. Early imaging, appropriate biopsy, and multidisciplinary management are essential to achieve optimal outcomes.

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原发性眼眶结外NK/ t细胞淋巴瘤：1例欧洲病例报告。

结外自然杀伤/ t细胞淋巴瘤，鼻型（ENKTL），是一种罕见的侵袭性恶性肿瘤。原发性眼眶受累极为罕见。我们报告一例眼窝ENKTL在白人患者呈现快速进展的眼窝症状。病例介绍：一名69岁女性，主要表现为眼睑肿胀、复视和突出眼。结膜炎的初步诊断由社区眼科医生证明无反应的治疗，促使转诊到三级眼科中心。眼眶磁共振显示球后肿块。活检证实Epstein-Barr病毒相关ENKTL，分期排除全身性疾病。患者接受年龄调整改良SMILE （mSMILE）化疗（地塞米松、甲氨蝶呤、异环磷酰胺、l-天冬酰胺酶、依托泊苷），同时接受铂基放化疗。她获得了完全的缓解，并报告了生活质量的显著改善。结论：对于进展迅速的眼窝疾病，即使是非常罕见的眼窝病变也应予以考虑。早期成像，适当的活检和多学科管理是实现最佳结果的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Ophthalmology OPHTHALMOLOGY-

CiteScore

0.90

自引率

0.00%

发文量

129

审稿时长

12 weeks

期刊介绍： This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of ophthalmology, including prevention, diagnosis, treatment, toxicities of therapy, supportive care, quality-of-life, and survivorship issues. The submission of negative results is strongly encouraged. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed. The intent of the journal is to provide clinicians and researchers with a tool to disseminate their personal experiences to a wider public as well as to review interesting cases encountered by colleagues all over the world. Universally used terms can be searched across the entire growing collection of case reports, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times.