Bibliometric Analysis of Research Hotspots and Emerging Trends in Mitochondrial DNA and Atherosclerosis (2004-2025).

IF 2.1 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Research and Practice Pub Date : 2026-06-21 eCollection Date: 2026-01-01 DOI:10.1155/crp/2121810

Yun Ouyang, Gesheng Wang, Ming Zhang, Puxuan Min, Mengxiong Guo

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引用次数: 0

Abstract

Objective: To explore the research course, hotspots, and development trends of mitochondrial DNA (mtDNA) and atherosclerosis (AS) based on knowledge graph technology, providing references for clinical and basic research in this field.

Methods: Publications themed on mtDNA and AS published between 2004 and 2025 were retrieved from the Web of Science Core Collection (WOSCC) database. CiteSpace 6.4. R1 Advanced software was used to construct and visually analyze knowledge graphs of authors, institutions, keywords, etc.

Results: A total of 341 publications were included, with the annual publication volume showing an overall upward trend. Research methods for mtDNA and AS are diversifying, with mechanistic investigations showing a trending focus toward specific molecular pathways. A total of 241 authors and 353 publishing institutions were analyzed. Ten keyword clusters were identified, including Cluster #0 oxidative stress, Cluster #1 mitochondrial DNA, Cluster #2 degradation, Cluster #3 atherosclerosis, Cluster #4 hydrogen peroxide, Cluster #5 roles, Cluster #6 MAPK pathway, Cluster #7 epigallocatechin gallate, Cluster #8 mitochondrial DNA copy number, and Cluster #9 vascular disease.

Conclusion: Research has evolved from foundational mechanistic studies to a focus on translational and clinical applications. Moving forward, efforts should be intensified to enhance collaboration among research teams and deepen mechanistic investigations, thereby laying a solid foundation for clinical translation.

查看原文本刊更多论文

线粒体DNA与动脉粥样硬化研究热点及新趋势的文献计量分析（2004-2025）。

目的：探讨基于知识图谱技术的线粒体DNA （mtDNA）与动脉粥样硬化（AS）的研究历程、研究热点及发展趋势，为该领域的临床和基础研究提供参考。方法：从Web of Science Core Collection （WOSCC）数据库中检索2004 ~ 2025年间发表的以mtDNA和AS为主题的出版物。CiteSpace 6.4。采用R1 Advanced软件构建作者、机构、关键词等知识图谱并进行可视化分析。结果：共纳入出版物341篇，年出版量总体呈上升趋势。mtDNA和AS的研究方法正在多样化，机制研究显示出对特定分子途径的关注趋势。共分析了241位作者和353家出版机构。确定了10个关键词集群，包括集群#0氧化应激、集群#1线粒体DNA、集群#2降解、集群#3动脉粥样硬化、集群#4过氧化氢、集群#5角色、集群#6 MAPK途径、集群#7表没食子儿茶素没食子酸酯、集群#8线粒体DNA拷贝数和集群#9血管疾病。结论：研究已经从基础机制研究发展到关注转化和临床应用。下一步，应加强研究团队之间的合作，深化机制研究，为临床转化奠定坚实的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiology Research and Practice Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Cardiology Research and Practice is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies that focus on the diagnosis and treatment of cardiovascular disease. The journal welcomes submissions related to systemic hypertension, arrhythmia, congestive heart failure, valvular heart disease, vascular disease, congenital heart disease, and cardiomyopathy.