Intersection of Pediatric Hypertension and Cardiovascular-Kidney-Metabolic Disease.

IF 6.3 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Hypertension Reports Pub Date : 2026-06-23 DOI:10.1007/s11906-026-01375-6

Jessica O'Keeffe, Christina Kingshill, Jack Tompson, Andrew M South, Carissa M Baker-Smith

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引用次数: 0

Abstract

Purpose of review: The purpose of this review is to describe the intersection between pediatric hypertension and advancing stages of cardiovascular, kidney metabolic syndrome in children and adolescents.

Recent findings: Cardiovascular-kidney-metabolic syndrome is highly prevalent in the pediatric population. The onset of CKM in childhood is influenced by the presence of antenatal risk factors such as maternal hypertensive disorders of pregnancy. Advancing stages of CKM in children and adolescents are strongly influenced by food insecurity and social determinants of health that impact the risk for childhood obesity. Activation of the renin-angiotensin-aldosterone system is a key mediator in the relationship between antenatal risk, early life course exposure and hypertension in children and adolescents. Effective strategies for slowing the rate of advancement of CKM staging in children and adolescents require attention to early course factors that influence the development of hypertension and obesity. Likewise, management strategies and therapeutic interventions that address these factors are critical to mitigating CKM stage advancement. Although hypertension is a component of the CKM framework, the presence of hypertension in children and adolescents drives higher CKM staging. Together, hypertension and higher CKM staging are associated with increased atherosclerotic cardiovascular disease risk. Social factors, including access to healthy foods and attention to early life course nutrition are critical strategies to improving CKM and hypertension related outcomes in children and adolescents.

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儿童高血压与心血管肾代谢性疾病的交叉。

综述目的：本综述的目的是描述儿童和青少年儿童高血压与进展期心血管、肾脏代谢综合征之间的交叉关系。最近发现：心血管肾代谢综合征在儿科人群中非常普遍。儿童期CKM的发病受产前危险因素的影响，如妊娠期孕妇高血压疾病。儿童和青少年CKM的进展阶段受到粮食不安全和影响儿童肥胖风险的健康社会决定因素的强烈影响。肾素-血管紧张素-醛固酮系统的激活是儿童和青少年产前风险、生命早期暴露和高血压之间关系的关键中介。减缓儿童和青少年CKM进展速度的有效策略需要关注影响高血压和肥胖发展的早期病程因素。同样，针对这些因素的管理策略和治疗干预对于缓解CKM阶段进展至关重要。虽然高血压是CKM框架的一个组成部分，但儿童和青少年高血压的存在导致CKM分期更高。总之，高血压和较高的CKM分期与动脉粥样硬化性心血管疾病风险增加相关。社会因素，包括获得健康食品和关注生命早期营养是改善儿童和青少年CKM和高血压相关结局的关键策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Hypertension Reports 医学-外周血管病

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.