Anti-inflammatory effect of Curcuma zedoaria ethanol extract on high-fat diet-induced obesity in mice.

IF 1.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2026-08-24 DOI:10.1093/bbb/zbag093

Kazuaki Yamasaki, Isoko Kuriyama

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引用次数: 0

Abstract

Curcuma zedoaria may serve as a promising material for preventing and/or improving lifestyle-related diseases, considering its known in vitro adiponectin-elevating effects. Here, we aimed to determine the effects of a C. zedoaria ethanol extract (CZE) on high-fat diet (HFD)-induced obesity in C57BL/6 N mice, to elucidate its effects on lifestyle-related diseases. CZE treatment with an HFD (HFD-CZE) reduced liver weight, subcutaneous fat, mesenteric fat, and hepatic lipid accumulation, along with alleviating the levels of plasma triglyceride, total-cholesterol, low density lipoprotein-cholesterol, aspartate aminotransferase, and alanine aminotransferase relative to those in the HFD group. Decreased messenger ribonucleic acid (mRNA) expressions of Tnfa and Il6 and increased mRNA expression of adiponectin were observed in epididymal white adipose tissue (eWAT) of the HFD-CZE group. CZE also reduced hepatic Tnfa and Fabp4 mRNA expressions. Thus, C. zedoaria may ameliorate obesity-induced whole-body inflammation, potentially aiding in preventing and improving obesity and subsequent lifestyle-related diseases.

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莪术乙醇提取物对小鼠高脂饮食性肥胖的抗炎作用。

考虑到其已知的体外脂联素升高作用，莪术可能作为预防和/或改善生活方式相关疾病的有前途的材料。在这里，我们旨在确定莪术乙醇提取物（CZE）对高脂肪饮食（HFD）诱导的C57BL/6 N小鼠肥胖的影响，以阐明其对生活方式相关疾病的影响。与HFD组相比，HFD-CZE治疗降低了肝脏重量、皮下脂肪、肠系膜脂肪和肝脏脂质积累，同时降低了血浆甘油三酯、总胆固醇、低密度脂蛋白胆固醇、天冬氨酸转氨酶和丙氨酸转氨酶的水平。HFD-CZE组附睾白色脂肪组织中tnf、Il6 mRNA表达降低，脂联素mRNA表达升高。CZE还降低了肝脏Tnfa和fabp4mrna的表达。因此，zedoaria可能改善肥胖引起的全身炎症，可能有助于预防和改善肥胖和随后的生活方式相关疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).