Interfacial engineering for enantioselective electrochemical sensing of tryptophan: materials, recognition strategies, and performance benchmarking

IF 2 4区化学 Q3 CHEMISTRY, ANALYTICAL

Analytical Sciences Pub Date : 2026-06-24 DOI:10.1007/s44211-026-00937-7

Alvin Lim Teik Zheng, Ellie Yi Lih Teo, Omar Faruqi Marzuki, Supakorn Boonyuen, Eric Lim Teik Chung, Kar Ban Tan, Yoshito Andou

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引用次数: 0

Abstract

The enantioselective detection of biologically active molecules is a vital analytical challenge, particularly for tryptophan (Trp), where the L- and D-enantiomers exhibit distinct physiological functions despite their near-identical properties. Electrochemical (EC) sensing offers a powerful solution, providing high sensitivity and miniaturization potential suitable for in situ monitoring. This review examines the state-of-the-art in EC chiral sensing of Trp, focusing on the integration of functional modifiers such as cyclodextrins (CDs), metal–organic frameworks (MOF), polymers/biopolymers, biomolecules and functional nanomaterials. We deconstruct the molecular recognition mechanisms focusing on enantioselectivity, including hydrogen bonding, π–π interactions, and steric complementarity, supported by theoretical modelling and experimental benchmarking. Furthermore, we evaluate emerging trends including microfluidic integration and AI-assisted signal processing while critically assessing current limitations in sensor stability and reproducibility. By linking interfacial mechanisms to sensing performance, this work provides comprehensive guidance for the rational design of EC platforms for point-of-care and environmental applications.

Graphical abstract

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色氨酸对映选择性电化学传感的界面工程：材料、识别策略和性能基准。

生物活性分子的对映体选择性检测是一个重要的分析挑战，特别是色氨酸（Trp），其中L-和d -对映体表现出不同的生理功能，尽管它们几乎相同的性质。电化学（EC）传感提供了一个强大的解决方案，提供高灵敏度和小型化的潜力，适合于现场监测。本文综述了色氨酸的EC手性传感技术的最新进展，重点介绍了环糊精（cd）、金属有机框架（MOF）、聚合物/生物聚合物、生物分子和功能纳米材料等功能改性剂的集成。我们解构了分子识别机制，重点是对映体选择性，包括氢键，π-π相互作用和立体互补，理论模型和实验基准的支持。此外，我们评估了包括微流控集成和人工智能辅助信号处理在内的新兴趋势，同时批判性地评估了传感器稳定性和可重复性方面的当前限制。通过将界面机制与传感性能联系起来，这项工作为护理点和环境应用的EC平台的合理设计提供了全面的指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical Sciences 化学-分析化学

CiteScore

2.90

自引率

18.80%

发文量

232

审稿时长

1 months

期刊介绍： Analytical Sciences is an international journal published monthly by The Japan Society for Analytical Chemistry. The journal publishes papers on all aspects of the theory and practice of analytical sciences, including fundamental and applied, inorganic and organic, wet chemical and instrumental methods. This publication is supported in part by the Grant-in-Aid for Publication of Scientific Research Result of the Japanese Ministry of Education, Culture, Sports, Science and Technology.