Rhabdomyolysis: a narrative review.

IF 1.9 4区医学 Q4 NEUROSCIENCES

Arquivos de neuro-psiquiatria Pub Date : 2026-05-01 Epub Date: 2026-06-23 DOI:10.1055/s-0046-1824437

Celia Harumi Tengan, Acary Souza Bulle Oliveira, Alzira Alves de Siqueira Carvalho, Cezar Daniel Snak de Souza, Claudia Ferreira da Rosa Sobreira, Edmar Zanoteli, Helga Cristina Almeida da Silva

{"title":"Rhabdomyolysis: a narrative review.","authors":"Celia Harumi Tengan, Acary Souza Bulle Oliveira, Alzira Alves de Siqueira Carvalho, Cezar Daniel Snak de Souza, Claudia Ferreira da Rosa Sobreira, Edmar Zanoteli, Helga Cristina Almeida da Silva","doi":"10.1055/s-0046-1824437","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Rhabdomyolysis is the acute necrosis of striated skeletal muscle, with release of its constituents into the extracellular space and circulation. Acute muscle pain (myalgia), weakness, and edema are associated with serum levels of the muscle enzyme creatine kinase (CK) above 1,000 IU/L or 5 times the upper limit of the normal value. This narrative review provides an overview of the clinical and laboratory findings, etiology, treatment, and prevention of rhabdomyolysis in humans. Additionally, we highlighted the main syndromes and muscular disorders associated with rhabdomyolysis: 1. Clinical syndromes: neuroleptic malignant syndrome, serotoninergic syndrome, sympathomimetic syndrome, malignant hyperthermia, and anesthesia-induced rhabdomyolysis; and 2. Myopathies: toxic myopathies, idiopathic inflammatory myopathies, muscular dystrophies, ion channel diseases, glycogen storage diseases, fatty acid beta oxidation defects, and mitochondrial myopathies.</p>","PeriodicalId":8694,"journal":{"name":"Arquivos de neuro-psiquiatria","volume":"84 5","pages":"1-13"},"PeriodicalIF":1.9000,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13290370/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arquivos de neuro-psiquiatria","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/s-0046-1824437","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/23 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Abstract: Rhabdomyolysis is the acute necrosis of striated skeletal muscle, with release of its constituents into the extracellular space and circulation. Acute muscle pain (myalgia), weakness, and edema are associated with serum levels of the muscle enzyme creatine kinase (CK) above 1,000 IU/L or 5 times the upper limit of the normal value. This narrative review provides an overview of the clinical and laboratory findings, etiology, treatment, and prevention of rhabdomyolysis in humans. Additionally, we highlighted the main syndromes and muscular disorders associated with rhabdomyolysis: 1. Clinical syndromes: neuroleptic malignant syndrome, serotoninergic syndrome, sympathomimetic syndrome, malignant hyperthermia, and anesthesia-induced rhabdomyolysis; and 2. Myopathies: toxic myopathies, idiopathic inflammatory myopathies, muscular dystrophies, ion channel diseases, glycogen storage diseases, fatty acid beta oxidation defects, and mitochondrial myopathies.

查看原文本刊更多论文

横纹肌溶解：叙述性回顾。

摘要横纹肌溶解是横纹肌的急性坏死，其成分释放到细胞外空间和循环中。急性肌肉疼痛（肌痛）、虚弱和水肿与血清肌酶肌酸激酶（CK）水平高于1,000 IU/L或正常值上限的5倍有关。本文综述了人类横纹肌溶解症的临床和实验室发现、病因、治疗和预防。此外，我们强调了与横纹肌溶解相关的主要综合征和肌肉疾病：临床综合征：抗精神病药恶性综合征、血清素能综合征、拟交感神经综合征、恶性高热、麻醉所致横纹肌溶解；和2。肌病：中毒性肌病、特发性炎性肌病、肌肉萎缩症、离子通道病、糖原蓄积病、脂肪酸β氧化缺陷、线粒体肌病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Arquivos de neuro-psiquiatria 医学-精神病学

CiteScore

2.10

自引率

7.10%

发文量

262

审稿时长

4-8 weeks

期刊介绍： Arquivos de Neuro-Psiquiatria is the official journal of the Brazilian Academy of Neurology. The mission of the journal is to provide neurologists, specialists and researchers in Neurology and related fields with open access to original articles (clinical and translational research), editorials, reviews, historical papers, neuroimages and letters about published manuscripts. It also publishes the consensus and guidelines on Neurology, as well as educational and scientific material from the different scientific departments of the Brazilian Academy of Neurology. The ultimate goals of the journal are to contribute to advance knowledge in the areas of Neurology and Neuroscience, and to provide valuable material for training and continuing education for neurologists and other health professionals working in the area. These goals might contribute to improving care for patients with neurological diseases. We aim to be the best Neuroscience journal in Latin America within the peer review system.