Multicomponent recognition and on-site detection of oral antidiabetic drugs based on a host-guest fluorescent sensor array.

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2026-12-01 Epub Date: 2026-06-18 DOI:10.1016/j.talanta.2026.130165

Hong-Yuan Hu, Qing Tang, Qing Fan, Jin-Xian Luo, Nan Dong, Zhu Tao, Ying Huang

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引用次数: 0

Abstract

Hypoglycemia, a serious complication of diabetes, requires prompt identification of its underlying cause. Unlike conventional lock-and-key methods, which generally require a dedicated sensor for each analyte, we constructed a supramolecular fluorescent sensor array for multiplex oral antidiabetic drug (OAD) detection using only two sensing units: cucurbit[8]uril (Q[8]) as the host, along with a synthesized bpep-Am derivative and palmatine as fluorescent probes. Upon introduction of OADs, competitive guest displacement generates differential fluorescence "fingerprints". In combination with linear discriminant analysis, the array fully discriminated five OADs (metformin, phenformin, buformin, rosiglitazone, and sitagliptin), with a detection limit as low as 0.218 μM, 100% classification accuracy in artificial urine and guinea pig serum, and >93% recovery for spiked sitagliptin and phenformin. The sensor array was further integrated into a smartphone-enabled portable device for rapid on-site visual quantification of sitagliptin. This strategy provides a promising tool for OAD screening and assessment of hypoglycemia etiology.

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基于主客体荧光传感器阵列的口服降糖药多组分识别及现场检测。

低血糖是糖尿病的一种严重并发症，需要及时查明其根本原因。与传统的锁与钥匙方法不同，该方法通常需要一个专用的传感器来检测每种分析物，我们构建了一个用于多重口服抗糖尿病药物（OAD）检测的超分子荧光传感器阵列，仅使用两个传感单元：瓜[8]uril （Q[8]）作为宿主，以及合成的bpeg - am衍生物和棕榈碱作为荧光探针。引入OADs后，竞争客体位移会产生不同的荧光“指纹”。结合线性判别分析，该阵列对二甲双胍、苯双胍、布双胍、罗格列酮和西格列汀5种oad进行了全面鉴别，检出限低至0.218 μM，对人工尿液和豚鼠血清的分类准确率为100%，对西格列汀和苯双胍的加标回收率为bb0 93%。传感器阵列进一步集成到支持智能手机的便携式设备中，用于快速现场视觉量化西格列汀。该策略为OAD筛查和低血糖病因评估提供了一个有前途的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.