Plasmon‐Enhanced NaYF ₄ :Yb/Er/Tm UCNPs Fluorescent Biosensing for Ultrasensitive Detection of GP73 in Clinical Liver Cancer Diagnosis

IF 12.1 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Rare Metals Pub Date : 2026-05-01 DOI:10.1002/rar2.70222

Changsheng Shi, Wei Cai, Zhixiang Lin, Y Xu, Liu Xu, Bingru Zheng, Wenhua Li, Hui Tong, Qing Yang, Caiping Ding, Youju Huang

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引用次数: 0

Abstract

ABSTRACT Early diagnosis of liver cancer demands high sensitivity, high specificity, convenience and real‐time monitoring capabilities. However, it encounters challenges such as low concentration of markers, numerous interfering factors, and limitations of detection technologies. This study investigates the potential of plasmonic gold nanorods (AuNRs) and rare‐earth‐based up‐conversion nanoparticles (NaYF 4 :Yb/Er/Tm UCNPs) in liver cancer surveillance and detection. A significant enhancement in Near‐infrared (NIR) fluorescence of the UCNPs was observed when the assay was used for detecting the serum biomarker Golgi protein 73 (GP73). The method enables ultra‐sensitive, quantitative detection of GP73 at concentrations as low as 5 ng mL −1 in a short period of time, using only 10 μL of serum samples. It demonstrated a sensitivity of 88.90% and a specificity of 100%, surpassing conventional immunoassays and showing strong agreement with Magnetic resonance imaging (MRI) and computed tomography (CT) in prognostic performance. Compared to existing advanced detection methods, this approach exhibited superior performance in diagnostic accuracy, cost‐effectiveness, and time efficiency, highlighting its high practical value and transformative potential. Based on the findings of this study, the rare‐earth‐plasmonic hybrid nanomaterials in the GP73 detection method show promise for future liver cancer diagnostics. Despite its simplicity, it offers potential applications in community screening, intraoperative assessment, and postoperative monitoring.

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等离子体增强的nayf4:Yb/Er/Tm UCNPs荧光生物传感技术在临床肝癌诊断中的超灵敏检测

肝癌早期诊断需要高灵敏度、高特异性、便捷性和实时监测能力。然而，它面临着标记物浓度低、干扰因素多、检测技术限制等挑战。本研究探讨了等离子体金纳米棒（aunr）和基于稀土的向上转化纳米颗粒（nayf4:Yb/Er/Tm UCNPs）在肝癌监测和检测中的潜力。用该方法检测血清生物标志物高尔基蛋白73 （GP73）时，发现UCNPs的近红外（NIR）荧光显著增强。该方法能够在短时间内，仅使用10 μL血清样品，在低至5 ng mL−1的浓度下，超灵敏地定量检测GP73。它的敏感性为88.90%，特异性为100%，超过了传统的免疫测定，在预后表现上与磁共振成像（MRI）和计算机断层扫描（CT）表现出强烈的一致性。与现有的先进检测方法相比，该方法在诊断准确性、成本效益和时间效率方面表现出优异的性能，突出了其较高的实用价值和变革潜力。基于本研究的发现，GP73检测方法中的稀土等离子体杂化纳米材料有望用于未来的肝癌诊断。尽管它简单，但它在社区筛查、术中评估和术后监测方面具有潜在的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rare Metals 工程技术-材料科学：综合

CiteScore

12.10

自引率

12.50%

发文量

2919

审稿时长

2.7 months

期刊介绍： Rare Metals is a monthly peer-reviewed journal published by the Nonferrous Metals Society of China. It serves as a platform for engineers and scientists to communicate and disseminate original research articles in the field of rare metals. The journal focuses on a wide range of topics including metallurgy, processing, and determination of rare metals. Additionally, it showcases the application of rare metals in advanced materials such as superconductors, semiconductors, composites, and ceramics.

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F-4700 fluorescence spectrophotometer

Plasmon‐Enhanced NaYF 4 :Yb/Er/Tm UCNPs Fluorescent Biosensing for Ultrasensitive Detection of GP73 in Clinical Liver Cancer Diagnosis

Abstract

Plasmon‐Enhanced NaYF ₄ :Yb/Er/Tm UCNPs Fluorescent Biosensing for Ultrasensitive Detection of GP73 in Clinical Liver Cancer Diagnosis