A reappraisal of APOE genetic effects on Alzheimer's disease risk in the Japanese population: a meta-analysis.

IF 19.6 1区医学 Q1 NEUROSCIENCES

Molecular Neurodegeneration Pub Date : 2026-06-24 DOI:10.1186/s13024-026-00963-z

Akinori Miyashita,Norikazu Hara,Ai Obinata,Tamao Tsukie,Mai Hasegawa,Takanobu Ishiguro,Kensaku Kasuga,Masataka Kikuchi,Tadafumi Hashimoto,Takahisa Kanekiyo,Takeshi Ikeuchi

引用次数: 0

Abstract

Our meta-analysis demonstrates that the risk effect of APOE-e4*4 relative to APOE-e3*3 for Alzheimer's disease in the Japanese population is approximately 12-15-fold, comparable to that reported in Caucasian populations, rather than greater than 20-fold as previously reported.

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APOE基因对日本人群阿尔茨海默病风险影响的重新评估：一项荟萃分析

我们的荟萃分析表明，APOE-e4*4相对于APOE-e3*3在日本人群中对阿尔茨海默病的风险效应大约是12-15倍，与在高加索人群中的报道相当，而不是之前报道的超过20倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Neurodegeneration 医学-神经科学

CiteScore

23.00

自引率

4.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Molecular Neurodegeneration, an open-access, peer-reviewed journal, comprehensively covers neurodegeneration research at the molecular and cellular levels. Neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's, and prion diseases, fall under its purview. These disorders, often linked to advanced aging and characterized by varying degrees of dementia, pose a significant public health concern with the growing aging population. Recent strides in understanding the molecular and cellular mechanisms of these neurodegenerative disorders offer valuable insights into their pathogenesis.