Incorporating Genetics Into Nephrology Practice—The New National Kidney Foundation Guidelines for Genetic Testing

Abstract

Genetic testing for kidney disease may inform clinical diagnosis, prognosis and therapy, help to guide transplant planning, and advise risk in relatives and family planning. This review provides a summary of the National Kidney Foundation report on testing genetic diseases for patients with chronic kidney disease and individuals who are at risk of chronic kidney disease, including family members and kidney donors, with an emphasis in monogenic disorders and APOL1. We illustrate medical decision-making using case-level interpretation for genetic disorders.