Association between chronic obstructive pulmonary disease and chronic rhinosinusitis: a longitudinal follow-up study using a national health insurance database.

IF 5.7 2区医学 Q1 OTORHINOLARYNGOLOGY

Rhinology Pub Date : 2026-10-01 DOI:10.4193/Rhin26.130

M W Park, H J Jung, H G Choi, J H Wee

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引用次数: 0

Abstract

Background: This study aimed to examine whether chronic obstructive pulmonary disease (COPD) is associated with the subsequentdevelopment of chronic rhinosinusitis (CRS) among Korean adults.

Methodology: Using the 2002â€"2019 Korean National Health Insurance database, we conducted a retrospective cohort study. Individuals with COPD, definted by relevant ICD-10 codes recorded on at least two occasions together with at least two prescriptions for COPD-related medicines (n=615,706), were matched with control participants (n=2,184,000) by age, sex, income, and region of residence. The incidence of CRS with and without nasal polyps was evaluated in both COPD and control groups. Hazard ratios (HRs) were estimated using stratified Cox proportional hazards models, and prespecified subgroup analyses were conducted.

Results: The incidence rate of CRS was higher in patients with COPD than in control participants. After adjustment, the HR for CRS was significantly higher in the COPD group compared with the control group. Likewise, the HRs for CRS with nasal polyps and CRS without nasal polyps were also significantly higher in the COPD group than in the control group. Statistical significance was observed in all subgroups according to age, sex, income, and region of residence. Kaplanâ€"Meier analyses showed a higher cumulative incidence in participants with COPD.

Conclusions: In this nationwide Korean cohort, COPD was associated with a higher incidence of CRS, both with and without nasal polyps.

查看原文本刊更多论文

慢性阻塞性肺疾病与慢性鼻窦炎之间的关系：一项使用国家健康保险数据库的纵向随访研究。

背景：本研究旨在探讨韩国成人慢性阻塞性肺疾病（COPD）是否与慢性鼻窦炎（CRS）的后续发展相关。方法：利用2002-2019年韩国国民健康保险数据库进行回顾性队列研究。根据年龄、性别、收入和居住地区，根据至少两次记录的相关ICD-10代码定义的COPD患者（n=615,706）与对照组（n=2,184,000）进行匹配。在COPD组和对照组中评估伴有和不伴有鼻息肉的CRS发生率。使用分层Cox比例风险模型估计风险比（hr），并进行预先指定的亚组分析。结果：慢性阻塞性肺病患者的CRS发生率高于对照组。经调整后，COPD组CRS的HR明显高于对照组。同样，慢性阻塞性肺病组伴有鼻息肉的CRS和无鼻息肉的CRS的hr也明显高于对照组。按年龄、性别、收入和居住地区划分的所有亚组均有统计学意义。Kaplan-Meier分析显示COPD患者的累积发病率更高。结论：在这个全国性的韩国队列中，COPD与CRS的高发生率相关，无论伴有或不伴有鼻息肉。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rhinology 医学-耳鼻喉科学

CiteScore

15.80

自引率

9.70%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Rhinology serves as the official Journal of the International Rhinologic Society and is recognized as one of the journals of the European Rhinologic Society. It offers a prominent platform for disseminating rhinologic research, reviews, position papers, task force reports, and guidelines to an international scientific audience. The journal also boasts the prestigious European Position Paper in Rhinosinusitis (EPOS), a highly influential publication first released in 2005 and subsequently updated in 2007, 2012, and most recently in 2020. Employing a double-blind peer review system, Rhinology welcomes original articles, review articles, and letters to the editor.