Surgical Outcomes and Prognostic Factors in Morning Glory Syndrome–Associated Retinal Detachment

IF 5.9 Q1 OPHTHALMOLOGY

Ophthalmology. Retina Pub Date : 2026-10-01 Epub Date: 2026-06-22 DOI:10.1016/j.oret.2026.06.011

Sayaka Yamao MD, PhD, Yasutaka Chiba PhD, Kazuki Kuniyoshi MD, PhD, Motohiro Kamei MD, PhD, Shunji Kusaka MD, PhD

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引用次数: 0

Abstract

Purpose

To evaluate surgical outcomes and identify key prognostic factors in retinal detachment (RD) associated with morning glory syndrome (MGS).

Design

Retrospective consecutive case series.

Subjects

Fifteen consecutive eyes of 15 patients with MGS-RD who underwent vitreoretinal surgery between 2000 and 2024 with a follow-up of >12 months.

Methods

We retrospectively reviewed clinical records. We analyzed associations between 7 clinical factors and outcomes using logistic regression and exact statistical methods, including age, proliferative vitreoretinopathy (PVR) grade, funnel configuration, extent of RD, the presence of a visible break, complicated cataract, and application of endolaser around the excavated peripapillary area.

Main Outcome Measures

Anatomic success was defined as retinal reattachment without silicone oil tamponade at final follow-up.

Results

The final anatomic success rate was 46.7% (7/15). Proliferative vitreoretinopathy grade at the initial surgery showed the strongest association with anatomic outcomes, with a success rate of 11.1% (1/9) in eyes with grade C compared with 100% (6/6) in those with less advanced PVR. Younger age was also associated with poorer outcomes, with no successful cases in patients aged ≤3 years (0/5) and complete success in those aged ≥9 years (5/5). Eyes with an open-funnel configuration showed higher success rates than those with a closed-funnel configuration (7/10 vs. 0/5). A visible peripapillary break and absence of complicated cataract were also associated with better outcomes. Endolaser application showed no clear association with success.

Conclusions

Advanced proliferative changes were strongly associated with poorer anatomic outcomes in MGS-RD. Younger age and advanced disease features, including closed-funnel configuration and complicated cataract, were also associated with poorer prognosis. Given the limited sample size and retrospective design, these findings should be interpreted as exploratory observations. Mild cases may initially be observed; however, we suggest that persistent or progressive detachment may warrant consideration of surgical intervention before severe proliferative progression develops.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

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牵牛花综合征相关性视网膜脱离的手术结果和预后因素。

目的：评价与牵牛花综合征（MGS-RD）相关的视网膜脱离的手术效果并确定关键预后因素。设计：回顾性连续病例系列。对象：15例MGS-RD患者，连续15只眼，于2000年至2024年间接受玻璃体视网膜手术，随访10 ~ 12个月。方法：回顾性分析临床资料。我们使用逻辑回归和精确统计方法分析了年龄、增殖性玻璃体视网膜病变（PVR）等级、漏斗结构、RD程度、可见破裂的存在、复杂的白内障以及在乳头周围挖出区域周围应用激光等七个临床因素与结果之间的关系。主要观察指标：解剖成功定义为最终随访时无硅油填塞的视网膜再植。结果：最终解剖成功率为46.7%（7/15）。初始手术时PVR等级与解剖结果的相关性最强，C级眼睛的手术成功率为11.1%(1/9)，而较不严重PVR的手术成功率为100%（6/6）。年龄较小也与预后较差相关，≤3岁（0/5）的患者没有成功病例，≥9岁（5/5）的患者完全成功。开漏斗结构的眼睛比闭漏斗结构的眼睛成功率更高（7/10 vs 0/5）。可见的乳头周围破裂和没有复杂的白内障也与较好的结果相关。endoolaser的应用与成功没有明确的联系。结论：MGS-RD的晚期增生性改变与较差的解剖结果密切相关。年龄越小，疾病特征越严重，包括闭漏斗结构和复杂的白内障，也与预后较差有关。考虑到有限的样本量和回顾性设计，这些发现应该被解释为探索性观察。最初可观察到轻度病例；然而，我们建议持续性或进行性脱离可能需要在发生严重增生进展之前考虑手术干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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