Septal melanoma: does surgical excision confer a potential survival benefit? A single centre's experience and literature review.

IF 1.1 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of Laryngology and Otology Pub Date : 2026-09-01 DOI:10.1017/S0022215126105283

Zakariya Sattar, Andrew James Mowat, James Barraclough

{"title":"Septal melanoma: does surgical excision confer a potential survival benefit? A single centre's experience and literature review.","authors":"Zakariya Sattar, Andrew James Mowat, James Barraclough","doi":"10.1017/S0022215126105283","DOIUrl":null,"url":null,"abstract":"Objectives: Intranasal melanoma is a rare, aggressive malignancy with poor prognosis, with five-year survival rates of 6-30 per cent. We hypothesised that intranasal melanoma confined to the nasal septum may have a more favourable outcome if detected early and treated with wide local excision or septectomy. This case series reviews management at a regional head and neck centre.Methods: Intranasal melanoma cases were identified from a list of those with International Classification of Diseases - Revision 10 code C30.0 (\"neoplasm of nasal cavity\") and analysed retrospectively for survival time and treatment modality.Results: Eleven patients (May 2010-December 2024) were identified. Eight (72.7 per cent) underwent surgery. Patients treated with subtotal septectomy or rhinectomy had longer mean survival (250 weeks) compared to those receiving endoscopic debulking and chemoradiotherapy (104 weeks).Conclusion: Our findings may identify utility of early septectomy in patients with septal disease. Furthermore, larger studies are required to elucidate the role of septectomy in septal intranasal melanoma.","PeriodicalId":16293,"journal":{"name":"Journal of Laryngology and Otology","volume":" ","pages":"993-997"},"PeriodicalIF":1.1000,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Laryngology and Otology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S0022215126105283","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Intranasal melanoma is a rare, aggressive malignancy with poor prognosis, with five-year survival rates of 6-30 per cent. We hypothesised that intranasal melanoma confined to the nasal septum may have a more favourable outcome if detected early and treated with wide local excision or septectomy. This case series reviews management at a regional head and neck centre.

Methods: Intranasal melanoma cases were identified from a list of those with International Classification of Diseases - Revision 10 code C30.0 ("neoplasm of nasal cavity") and analysed retrospectively for survival time and treatment modality.

Results: Eleven patients (May 2010-December 2024) were identified. Eight (72.7 per cent) underwent surgery. Patients treated with subtotal septectomy or rhinectomy had longer mean survival (250 weeks) compared to those receiving endoscopic debulking and chemoradiotherapy (104 weeks).

Conclusion: Our findings may identify utility of early septectomy in patients with septal disease. Furthermore, larger studies are required to elucidate the role of septectomy in septal intranasal melanoma.

查看原文本刊更多论文

鼻中隔黑色素瘤：手术切除是否具有潜在的生存益处？单一中心的经验和文献综述。

目的：鼻内黑色素瘤是一种罕见的、侵袭性的恶性肿瘤，预后差，5年生存率为6- 30%。我们假设，如果早期发现鼻中隔的鼻内黑色素瘤，并进行大面积局部切除或鼻中隔切除术，可能会有更有利的结果。本病例系列回顾了区域头颈中心的管理。方法：从国际疾病分类-修订10代码C30.0（“鼻腔肿瘤”）列表中确定鼻内黑色素瘤病例，并回顾性分析其生存时间和治疗方式。结果：11例患者（2010年5月- 2024年12月）被确诊。其中8人（72.7%）接受了手术。与接受内窥镜减容和放化疗（104周）的患者相比，接受次全隔切除术或鼻切除术的患者平均生存期（250周）更长。结论：我们的研究结果可以确定早期鼻中隔切除术在鼻中隔疾病患者中的作用。此外，需要更大规模的研究来阐明鼻中隔切除术在鼻中隔黑色素瘤中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.