Effect of Vitamin B12 supplementation on glycemic control, albuminuria and peripheral neuropathy in diabetes mellitus patients - a cross sectional study.

IF 1.9 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Hormone Molecular Biology and Clinical Investigation Pub Date : 2026-06-24 eCollection Date: 2026-09-01 DOI:10.1515/hmbci-2026-0016

Rahul Kumar, Pinky Garg, Mansi Modi, Deepak Das, Harshvardan Singh

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引用次数: 0

Abstract

Objectives: Type 2 Diabetes Mellitus (T2DM) is a global health challenge linked to microvascular complications like neuropathy and nephropathy. Metformin, first-line therapy, is associated with Vitamin B12 deficiency, potentially worsening neurological outcomes. This study assessed B12 supplementation's association with glycemic control, albuminuria, and peripheral neuropathy.

Methods: A cross-sectional study at Hindu Rao Hospital, New Delhi, included 151 T2DM patients (≥30 years) on B12 supplementation. Serum B12, HbA_1c, and urinary albumin-creatinine ratio (ACR) were measured. Neuropathy was evaluated using the Diabetic Neuropathy Symptom (DNS) score. Analysis used SPSS v23; (p<0.05) was significant.

Results: Mean age was 50.79 ± 9.60 years (63.6 % female). Neuropathy prevalence (DNS≥1) was 76.8 %. Mean B12 was 452.25 ± 360.86 pg/mL. B12 levels differed significantly across glycemic groups (p<0.001), highest in HbA_1c>8.5 %. Neuropathy associated with B12 levels (p=0.027) and oral hypoglycemic use (p=0.010). Logistic regression showed higher B12 paradoxically linked to neuropathy (AOR=1.003; (p=0.023)). No ACR difference (p=0.879).

Conclusions: B12 shows complex ties to neuropathy and glycemic control in supplemented T2DM patients. Elevated serum levels may not indicate functional adequacy; monitoring functional markers like homocysteine or methylmalonic acid is recommended.

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补充维生素B12对糖尿病患者血糖控制、蛋白尿和周围神经病变的影响——一项横断面研究

目的：2型糖尿病（T2DM）是一个全球性的健康挑战，与微血管并发症如神经病变和肾病有关。二甲双胍作为一线治疗药物，与维生素B12缺乏有关，可能会使神经系统预后恶化。这项研究评估了B12补充剂与血糖控制、蛋白尿和周围神经病变的关系。方法：在新德里兴都拉奥医院进行横断面研究，纳入151例补充B12的T2DM患者（≥30岁）。测定血清B12、HbA1c、尿白蛋白-肌酐比值（ACR）。采用糖尿病神经病变症状（DNS）评分评估神经病变。分析采用SPSS v23；（结果）平均年龄50.79±9.60岁，女性占63.6% 。神经病变患病率（DNS≥1）为76.8% %。平均B12为452.25±360.86 pg/mL。不同血糖组的B12水平差异显著（p1c>8.5 %）。神经病变与B12水平（p=0.027）和口服降糖药（p=0.010）相关。逻辑回归显示，较高的B12与神经病变有矛盾的联系（AOR=1.003; (p=0.023)）。ACR无差异（p=0.879）。结论：B12与补充型T2DM患者的神经病变和血糖控制有复杂的关系。血清水平升高可能并不表明功能充足；建议监测功能标记物，如同型半胱氨酸或甲基丙二酸。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone Molecular Biology and Clinical Investigation BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： Hormone Molecular Biology and Clinical Investigation (HMBCI) is dedicated to the provision of basic data on molecular aspects of hormones in physiology and pathophysiology. The journal covers the treatment of major diseases, such as endocrine cancers (breast, prostate, endometrium, ovary), renal and lymphoid carcinoma, hypertension, cardiovascular systems, osteoporosis, hormone deficiency in menopause and andropause, obesity, diabetes, brain and related diseases, metabolic syndrome, sexual dysfunction, fetal and pregnancy diseases, as well as the treatment of dysfunctions and deficiencies. HMBCI covers new data on the different steps and factors involved in the mechanism of hormone action. It will equally examine the relation of hormones with the immune system and its environment, as well as new developments in hormone measurements. HMBCI is a blind peer reviewed journal and publishes in English: Original articles, Reviews, Mini Reviews, Short Communications, Case Reports, Letters to the Editor and Opinion papers. Ahead-of-print publishing ensures faster processing of fully proof-read, DOI-citable articles.