Dietary glycemic index/glycemic load and knee osteoarthritis: associations with inflammation and oxidative stress.

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine Pub Date : 2026-06-01 Epub Date: 2026-06-23 DOI:10.1080/17520363.2026.2692040

Farshad Amirkhizi, Filiz Mercantepe, Soudabeh Hamedi-Shahraki, Aleksandra Klisic

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引用次数: 0

Abstract

Aims: Although dietary glycemic index (GI) and glycemic load (GL) are known to affect inflammation and oxidative balance, their roles in OA are unclear. This study aims to investigate the relationship between dietary GI and GL with inflammation, oxidative stress, and clinical symptoms in patients with knee osteoarthritis (KOA).

Patients and methods: In a cross-sectional study, 160 patients diagnosed with KOA were included. Dietary intake was assessed using a validated food frequency questionnaire, and daily GI and GL values were calculated. Clinical symptoms were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).

Results: Higher dietary GI and GL were significantly associated with increased serum levels of malondialdehyde (MDA), total oxidant status (TOS), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP), as well as with decreased total antioxidant capacity (TAC). Dietary GI and GL were positively correlated with the total WOMAC score, as well as with the WOMAC physical activity and stiffness.

Conclusion: High dietary GI and GL may be associated with oxidative stress and inflammatory responses, and may worsen clinical symptoms in KOA patients. Nutritional strategies emphasizing low-GI/GL diets may contribute to better symptom control and disease management in KOA.

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膳食血糖指数/血糖负荷与膝关节骨关节炎：与炎症和氧化应激的关系。

目的：虽然已知膳食血糖指数（GI）和血糖负荷（GL）会影响炎症和氧化平衡，但它们在OA中的作用尚不清楚。本研究旨在探讨膳食GI和GL与膝关节骨关节炎（KOA）患者炎症、氧化应激和临床症状的关系。患者和方法：在一项横断面研究中，纳入了160例确诊为KOA的患者。采用有效的食物频率问卷评估膳食摄入量，并计算每日GI和GL值。临床症状评估使用西安大略和麦克马斯特大学骨关节炎指数（WOMAC）。结果：较高的膳食GI和GL与血清丙二醛（MDA）、总氧化状态（TOS）、肿瘤坏死因子-α (TNF-α)和高敏c反应蛋白（hs-CRP）水平升高以及总抗氧化能力（TAC）降低显著相关。膳食GI和GL与WOMAC总分、WOMAC体力活动和僵硬度呈正相关。结论：高GI和GL可能与氧化应激和炎症反应有关，并可能加重KOA患者的临床症状。强调低gi /GL饮食的营养策略可能有助于更好地控制KOA的症状和疾病管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomarkers in medicine 医学-医学：研究与实验

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory. Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice. As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications. Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest. Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.