The potential impact of reduced donor funding for HIV programs on Malawi's disease burden.

IF 2.9 2区 医学 Q3 IMMUNOLOGY
AIDS Pub Date : 2026-11-01 Epub Date: 2026-06-16 DOI:10.1097/QAD.0000000000004568
Vasiliki Votsika, Sakshi Mohan, Andrew Phillips, Tim Colbourn, Joseph H Collins, Rachel Murray-Watson, Pemphero Norah Mphamba, Bingling She, Tara D Mangal, Timothy B Hallett, Paul Revill, Margherita Molaro
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Abstract

Objectives: HIV care in Malawi has been primarily funded through overseas development assistance for health, leading to the establishment of vertically-funded supply chains of key HIV medicines and diagnostics. Cuts in this funding could undermine healthcare services and the success of these supply chains.

Design: Using the Thanzi La Onse model, we estimate the potential impact of reduced availability of HIV-related consumables that could result from reduced external funding.

Methods: We consider a shift in HIV consumable availability from the high levels achieved currently (≥93% for adult ART and ≥85% for HIV tests in relevant facility levels) to levels comparable to those observed within government-funded integrated supply chains in other areas of health (44-76% and 44-73%, respectively). We assume that if key medicines/diagnostics are not available, a patient's care is delayed or interrupted. We measure the consequences in terms of disability-adjusted life years (DALYs) and AIDS deaths over the period 2025-2040.

Results: A reduction in HIV consumable availability could cause a substantial increase in HIV/AIDS-related DALYs, with projected increases exceeding 144% compared with the status quo. Mortality rises sharply within the first 4-5 years of the simulation, as continuity of care is disrupted for the large cohort of people currently on ART, demonstrating the rapid and severe consequences of reduced access to essential HIV consumables.

Conclusions: This study highlights the risks to HIV programs in Malawi from reduced external funding, emphasising the need for governments to sustain current levels of HIV medicines and diagnostics beyond donor funding.

减少艾滋病项目捐赠资金对马拉维疾病负担的潜在影响。
目标:马拉维的艾滋病毒护理主要由海外保健发展援助供资,从而建立了由纵向供资的关键艾滋病毒药品和诊断品供应链。这种资金的削减可能会破坏医疗保健服务和这些供应链的成功。设计:使用Thanzi La Onse模型,我们估计了外部资金减少可能导致艾滋病相关消耗品可获得性降低的潜在影响。方法:我们考虑艾滋病毒消耗品可获得性从目前达到的高水平(成人抗逆转录病毒治疗≥93%,相关设施水平的艾滋病毒检测≥85%)转变为与政府资助的其他卫生领域综合供应链中观察到的水平相当(分别为44-76%和44-73%)。我们假设,如果无法获得关键药物/诊断,患者的护理就会延迟或中断。我们根据2025-2040年期间的残疾调整生命年(DALYs)和艾滋病死亡人数来衡量后果。结果:艾滋病毒消耗品可获得性的降低可能导致艾滋病毒/艾滋病相关DALYs大幅增加,与现状相比,预计增幅将超过144%。死亡率在模拟的头4-5年内急剧上升,因为目前正在接受抗逆转录病毒治疗的一大群人的护理连续性中断,这表明减少获得基本艾滋病毒消耗品的迅速和严重后果。结论:这项研究强调了外部资金减少给马拉维艾滋病项目带来的风险,强调了政府需要在捐赠资金之外维持目前的艾滋病药物和诊断水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AIDS
AIDS 医学-病毒学
CiteScore
5.90
自引率
5.30%
发文量
478
审稿时长
3 months
期刊介绍: ​​​​​​​​​​​​​​​​​Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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