NIR-responsive MnO₂-functionalized mesoporous silica hydrogel: Fabrication and antibacterial activity evaluation.

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2026-12-01 Epub Date: 2026-06-20 DOI:10.1016/j.talanta.2026.130186

Xue Yang, Yu Si, Shasha Jiang, Meng Zhuo, Tong Ren, Zijun Han, Xuetong Zhao, Xueyan Hou, Yongli Shi

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引用次数: 0

Abstract

In this study, an 808 nm near-infrared (NIR)-responsive hydrogel (NOR-MSN@MnO₂-gel) was developed for the treatment of bacteria-infected wounds. The norfloxacin (NOR)-loaded manganese dioxide-modified mesoporous silica (NOR-MSN@MnO₂) nanoparticles were selected as a photothermal material and encapsulated in the furfuryl amine-modified hyaluronic acid hydrogel (HA-FA^gel). Studies found that MSN@MnO₂-gel exhibited a three-dimensional porous network structure, favorable injectability, excellent water absorption & retention capacity, and desirable photothermal conversion efficiency. Benefiting from pH/NIR dual-responsive characteristics, NOR-MSN@MnO₂-gel realized controllable NOR release and achieved efficient elimination of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) through synergistic photothermal therapy (PTT) and chemotherapy. In vivo infected wound studies demonstrated that NOR-MSN@MnO₂-gel combined with NIR irradiation (NOR-MSN@MnO₂-gel + NIR) could effectively inhibit bacterial growth, alleviate inflammation, accelerate re-epithelialization, and promote collagen deposition & angiogenesis, while maintaining satisfactory biological safety. Collectively, the NOR-MSN@MnO₂-gel + NIR regimen provides a promising strategy for clinical treatment of bacterial infected wounds.

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nir响应mno2功能化介孔二氧化硅水凝胶的制备及其抗菌活性评价。

在这项研究中，研制了808 nm近红外（NIR）响应水凝胶（NOR-MSN@MnO2-gel），用于治疗细菌感染的伤口。选择负载诺氟沙星（NOR）的二氧化锰修饰介孔二氧化硅（NOR-MSN@MnO2）纳米颗粒作为光热材料，包被在糠胺修饰透明质酸水凝胶（HA-FAgel）中。研究发现MSN@MnO2-gel具有三维多孔网络结构、良好的可注入性、优异的吸水保水性和理想的光热转换效率。NOR-MSN@MnO2-gel利用pH/NIR双响应特性，实现可控NOR释放，通过光热协同治疗（PTT）和化疗，实现对金黄色葡萄球菌（S. aureus）和大肠杆菌（E. coli）的高效清除。体内感染创面研究表明，NOR-MSN@MnO2-gel联合NIR照射（NOR-MSN@MnO2-gel + NIR）可有效抑制细菌生长，减轻炎症，加速再上皮化，促进胶原沉积和血管生成，同时保持满意的生物安全性。总的来说，NOR-MSN@MnO2-gel + NIR方案为临床治疗细菌感染伤口提供了一个有希望的策略。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.