Multifunctional copper tripeptide-1/nanocellulose composite hydrogels

IF 2.9 4区化学 Q3 CHEMISTRY, PHYSICAL

Colloid and Polymer Science Pub Date : 2026-05-04 DOI:10.1007/s00396-026-05624-7

Xinqiao Xia, Lingli Zhang, Chengji Ma, Fangjie Wang, Xinyu Ren, Jia Zhou, Zhongbiao Tan, Ya Xin, Hao Shi

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Abstract

This study reports the rational design and fabrication of a novel multifunctional composite hydrogel by integrating copper tripeptide-1 (GHK-Cu) with cellulose nanocrystals (CNC). Fourier-transform infrared spectroscopy and scanning electron microscopy analyses verified the formation of a stable, physically crosslinked three-dimensional network between GHK-Cu and CNC. Mechanical characterization demonstrated outstanding flexibility, with an elongation at break reaching 1303%, markedly superior to that of single-component hydrogels. The composite hydrogel also exhibited a high swelling capacity in physiological saline, achieving a swelling ratio of up to 936%. Furthermore, incorporation of β-cyclodextrin-encapsulated menthol imparted pronounced antibacterial activity to the hydrogel. In addition, the material showed excellent pronounced ABTS radical-scavenging activity (> 95%), whereas the DPPH scavenging response was comparatively modest. Collectively, these results highlight the significant potential of the GHK-Cu/CNC composite hydrogel for applications in wound dressings, tissue engineering, and other biomedical fields.

Graphical Abstract

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多功能铜三肽-1/纳米纤维素复合水凝胶

本文报道了一种将三肽铜-1 （GHK-Cu）与纤维素纳米晶体（CNC）结合的新型多功能复合水凝胶的合理设计和制备。傅里叶变换红外光谱和扫描电镜分析证实了GHK-Cu和CNC之间形成了一个稳定的、物理交联的三维网络。力学性能表现出优异的柔韧性，断裂伸长率达到1303%，明显优于单组分水凝胶。复合水凝胶在生理盐水中也表现出较高的溶胀能力，溶胀率高达936%。此外，掺入β-环糊精包封的薄荷醇使水凝胶具有明显的抗菌活性。此外，该材料显示出优异的ABTS自由基清除活性（> 95%），而DPPH清除反应相对温和。总之，这些结果突出了GHK-Cu/CNC复合水凝胶在伤口敷料、组织工程和其他生物医学领域应用的巨大潜力。图形抽象

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来源期刊

Colloid and Polymer Science 化学-高分子科学

CiteScore

4.60

自引率

4.20%

发文量

111

审稿时长

2.2 months

期刊介绍： Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.