Clinical significance of the C-reactive protein-albumin-lymphocyte index in older patients with colorectal cancer.

IF 2.3 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2026-10-01 Epub Date: 2026-06-20 DOI:10.1007/s00595-026-03318-9

Daiki Matsubara, Miki Tanaka, Atsuhito Ando, Atsushi Matsumura, Satoshi Mochizuki, Koji Miyagawa, Nobuaki Fuji, Atsushi Shiozaki

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引用次数: 0

Abstract

Purpose: This study aimed to investigate the association between the C-reactive protein-albumin-lymphocyte (CALLY) index and long-term prognosis and postoperative complications in older patients with colorectal cancer (CRC).

Methods: Three hundred three patients with pathological stage (pStage) I-III CRC who underwent curative surgery at our institution between 2015 and 2022 were retrospectively analyzed. Patients aged ≥ 75 years were defined as older.

Results: In the overall cohort, a low CALLY index was an independent prognostic factor (hazard ratio (HR) = 2.42, 95% confidence interval (CI): 1.31-4.47, p = 0.004). The age-stratified analysis revealed that a low CALLY index was associated with a worse prognosis and was an independent prognostic factor in older patients (HR = 3.46, 95% CI: 1.44-8.30, p = 0.005), whereas no independent prognostic significance was observed in non-older patients. Moreover, although the CALLY index was not associated with postoperative complications in non-older patients, a low CALLY index was an independent risk factor for postoperative complications in older patients (odds ratio = 3.93, 95% CI 1.49-10.3, p = 0.005).

Conclusion: The CALLY index is a valuable predictor of both short- and long-term outcomes in patients with pStage I-III CRC, with a particularly strong impact on older patients aged ≥ 75 years.

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老年结直肠癌患者c反应蛋白-白蛋白淋巴细胞指数的临床意义

目的：探讨老年结直肠癌（CRC）患者c反应蛋白-白蛋白淋巴细胞（CALLY）指数与远期预后及术后并发症的关系。方法：回顾性分析2015年至2022年在我院行根治性手术的病理期（pStage） I-III型结直肠癌患者300例。年龄≥75岁的患者被定义为老年。结果：在整个队列中，低CALLY指数是一个独立的预后因素(风险比（HR) = 2.42, 95%可信区间（CI）： 1.31-4.47, p = 0.004）。年龄分层分析显示，较低的CALLY指数与较差的预后相关，并且是老年患者的独立预后因素（HR = 3.46, 95% CI: 1.44-8.30, p = 0.005），而在非老年患者中未观察到独立预后意义。此外，尽管CALLY指数与非老年患者术后并发症无关，但低CALLY指数是老年患者术后并发症的独立危险因素（优势比= 3.93,95% CI 1.49-10.3, p = 0.005）。结论：CALLY指数是pi - iii期CRC患者短期和长期预后的有价值的预测指标，对年龄≥75岁的老年患者影响特别大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.