Tomasz Muszyński, Tomasz Jędrychowski, Adrianna Witalewska, Aldona Gawlewicz-Czepiel, Karina Polak, Michał Spieszny, Piotr Richter, Antoni Szczepanik, Kołodziejczyk Piotr
{"title":"Metabolic and nutritional impact of gastrectomy and perioperative treatment in gastric cancer: a prospective cohort study.","authors":"Tomasz Muszyński, Tomasz Jędrychowski, Adrianna Witalewska, Aldona Gawlewicz-Czepiel, Karina Polak, Michał Spieszny, Piotr Richter, Antoni Szczepanik, Kołodziejczyk Piotr","doi":"10.1186/s43046-026-00367-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gastrectomy due to gastric cancer leads to metabolic alterations in body composition, significantly affecting nutritional status. This prospective study aimed to investigate the metabolic effects of gastrectomy and perioperative treatment on the nutritional status of gastric cancer patients.</p><p><strong>Methods: </strong>A total of 37 patients diagnosed with gastric cancer, treated with perioperative chemotherapy, without evidence of dissemination or metastasis, were included in the study. Demographic data, Body Mass Index, full blood count parameters, lipid profiles, vitamin B12, vitamin D, iron levels, albumin, prealbumin, total serum protein concentration, bioimpedance parameters, physical activity levels, quality of life, Prognostic Nutritional Index, neutrophil-to-lymphocyte ratio, and systemic immune-inflammation index were assessed preoperatively and at two follow-ups (6 and 12 months post-surgery) for each patient.</p><p><strong>Results: </strong>Significant changes were observed across the analyzed parameters, demonstrating the metabolic impact of gastrectomy and perioperative systemic treatment on the nutritional status of gastric cancer patients.</p><p><strong>Conclusions: </strong>The study provides a comprehensive evaluation of the long-term nutritional status of gastric cancer patients post-gastrectomy, offering valuable insights into postoperative metabolic and dietary adaptations. Obtained results underscore the dynamic physiological adaptations following gastric resection, emphasizing the importance of nutritional and metabolic monitoring for long-term recovery. Targeted rehabilitation strategies and micronutrient supplementation are crucial in reducing postoperative complications and improving patient outcomes.</p>","PeriodicalId":17301,"journal":{"name":"Journal of the Egyptian National Cancer Institute","volume":"38 1","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13313303/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Egyptian National Cancer Institute","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s43046-026-00367-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Gastrectomy due to gastric cancer leads to metabolic alterations in body composition, significantly affecting nutritional status. This prospective study aimed to investigate the metabolic effects of gastrectomy and perioperative treatment on the nutritional status of gastric cancer patients.
Methods: A total of 37 patients diagnosed with gastric cancer, treated with perioperative chemotherapy, without evidence of dissemination or metastasis, were included in the study. Demographic data, Body Mass Index, full blood count parameters, lipid profiles, vitamin B12, vitamin D, iron levels, albumin, prealbumin, total serum protein concentration, bioimpedance parameters, physical activity levels, quality of life, Prognostic Nutritional Index, neutrophil-to-lymphocyte ratio, and systemic immune-inflammation index were assessed preoperatively and at two follow-ups (6 and 12 months post-surgery) for each patient.
Results: Significant changes were observed across the analyzed parameters, demonstrating the metabolic impact of gastrectomy and perioperative systemic treatment on the nutritional status of gastric cancer patients.
Conclusions: The study provides a comprehensive evaluation of the long-term nutritional status of gastric cancer patients post-gastrectomy, offering valuable insights into postoperative metabolic and dietary adaptations. Obtained results underscore the dynamic physiological adaptations following gastric resection, emphasizing the importance of nutritional and metabolic monitoring for long-term recovery. Targeted rehabilitation strategies and micronutrient supplementation are crucial in reducing postoperative complications and improving patient outcomes.
期刊介绍：
As the official publication of the National Cancer Institute, Cairo University, the Journal of the Egyptian National Cancer Institute (JENCI) is an open access peer-reviewed journal that publishes on the latest innovations in oncology and thereby, providing academics and clinicians a leading research platform. JENCI welcomes submissions pertaining to all fields of basic, applied and clinical cancer research. Main topics of interest include: local and systemic anticancer therapy (with specific interest on applied cancer research from developing countries); experimental oncology; early cancer detection; randomized trials (including negatives ones); and key emerging fields of personalized medicine, such as molecular pathology, bioinformatics, and biotechnologies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
