Songling Lei, Dan Chen, Junliang Wu, Kewang Hu, Mingli Zhu
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引用次数: 0
Abstract
Abstract: Bacteria enter the L-form state after shedding their cell walls in response to adverse conditions for survival; these bacteria can revert to their walled morphology after the unfavorable factors are removed. Bacterial L-forms can be either unstable (typically observed in clinically isolated and induced L-forms) or stable (associated with two specific mutation types). In recent years, bacterial L-forms have been implicated in antibiotic resistance, disease recurrence, and origin of life. However, because identifying bacterial L-forms is difficult, they are often overlooked in clinical settings. In this review, we elucidate the relationships of bacterial L-forms with their cell walls, mutation, proliferation, antibiotic resistance, and disease recurrence, as well as with the host immune system. We also highlight the challenges and future prospects for bacterial L-form research.
期刊介绍：
Indian Journal of Microbiology is the official organ of the Association of Microbiologists of India (AMI). It publishes full-length papers, short communication reviews and mini reviews on all aspects of microbiological research, published quarterly (March, June, September and December). Areas of special interest include agricultural, food, environmental, industrial, medical, pharmaceutical, veterinary and molecular microbiology.
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