{"title":"Biological Applications of Functionalized Cerium Oxide Nanoparticles.","authors":"Siyu Chen, Yuqi Gong, Fagang Jiang, Xinghua Wang","doi":"10.7150/ijms.134122","DOIUrl":null,"url":null,"abstract":"<p><p>The rapid expansion and advancement of nanotechnology have presented potential applications in the diagnosis and treatment of various diseases. In recent years, cerium oxide nanoparticles (CeO<sub>2</sub> NPs) have been extensively studied and applied in biological systems due to their unique physical and chemical properties, such as high antioxidant activity, enzyme-mimicking activity and good biocompatibility. This review summarizes the latest research progress of functionalized CeO<sub>2</sub> NPs in anti-cancer activity, anti-infection, anti-inflammation, antioxidant activity, wound healing, neuroprotection and imaging applications. It explores their mechanisms of action and potential clinical application prospects, as well as the concerns about toxicity and safety.</p>","PeriodicalId":14031,"journal":{"name":"International Journal of Medical Sciences","volume":"23 7","pages":"2328-2354"},"PeriodicalIF":3.7000,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280748/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7150/ijms.134122","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
The rapid expansion and advancement of nanotechnology have presented potential applications in the diagnosis and treatment of various diseases. In recent years, cerium oxide nanoparticles (CeO2 NPs) have been extensively studied and applied in biological systems due to their unique physical and chemical properties, such as high antioxidant activity, enzyme-mimicking activity and good biocompatibility. This review summarizes the latest research progress of functionalized CeO2 NPs in anti-cancer activity, anti-infection, anti-inflammation, antioxidant activity, wound healing, neuroprotection and imaging applications. It explores their mechanisms of action and potential clinical application prospects, as well as the concerns about toxicity and safety.
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Original research papers, reviews, and short research communications in any medical related area can be submitted to the Journal on the understanding that the work has not been published previously in whole or part and is not under consideration for publication elsewhere. Manuscripts in basic science and clinical medicine are both considered. There is no restriction on the length of research papers and reviews, although authors are encouraged to be concise. Short research communication is limited to be under 2500 words.
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