Disseminated Angioinvasive Fusarium Infection following Chimeric Antigen Receptor T-Cell Therapy in Refractory Diffuse Large B-Cell Lymphoma: A Case Report.

IF 0.7 Q4 ONCOLOGY

Case Reports in Oncology Pub Date : 2026-04-13 eCollection Date: 2026-01-01 DOI:10.1159/000552005

Mary V Lang, Alicia Hou, Matthew Kornas, Valandrea Merilan, Ryan Skelly, Ricky Buckshaw

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Abstract

Introduction: Patients receiving immune-directed chimeric antigen receptor T-cell (CAR-T) therapy experience profound, prolonged immunosuppression, predisposing them to opportunistic infections. Disseminated angioinvasive Fusarium infections are uncommon but carry high morbidity and mortality in this population.

Case presentation: We describe a rare case of disseminated angioinvasive Fusarium infection in a patient with refractory diffuse large B-cell lymphoma following CD19-directed CAR-T-cell therapy. The patient developed progressive cutaneous lesions due to Fusarium keratoplasticum complex, confirmed by tissue culture and histopathology. She ultimately expired due to septic shock complicated by multifactorial cardiotoxicity.

Conclusion: This case highlights the heightened susceptibility to refractory opportunistic mold infections and potential cardiac complications in patients after CAR-T therapy. New skin lesions in the post-CAR-T period should prompt early biopsy and skin culture with prompt mold coverage.

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嵌合抗原受体t细胞治疗难治性弥漫性大b细胞淋巴瘤后弥散性血管侵袭性镰刀菌感染1例报告。

接受免疫定向嵌合抗原受体t细胞（CAR-T）治疗的患者经历了深刻的、长期的免疫抑制，使他们容易发生机会性感染。弥散性血管浸润性镰刀菌感染并不常见，但在这一人群中发病率和死亡率很高。病例介绍：我们报告一例罕见的弥漫性大b细胞淋巴瘤患者在接受cd19定向car - t细胞治疗后发生弥漫性血管侵袭性镰刀菌感染。经组织培养和组织病理学证实，患者因角膜变形镰刀菌复合体出现进行性皮肤病变。她最终因感染性休克合并多因素心脏毒性而死亡。结论：本病例突出了CAR-T治疗后患者对难治性机会性霉菌感染和潜在心脏并发症的易感性增加。car - t后出现的新皮肤病变应及早进行活检和皮肤培养，并及时进行霉菌覆盖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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