A wirelessly powered, light-controlled, bioresorbable stimulation system with programmable polyphasic waveforms

IF 42.3 1区工程技术 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

Nature Electronics Pub Date : 2026-06-16 DOI:10.1038/s41928-026-01655-8

Jong Uk Kim, Seung Gi Seo, Hongkai Wang, Eric Rytkin, Jiarui Gong, Jie Zhou, Junhwan Choi, Jiwon Kim, Sun Young Park, Anna Pfenniger, Rishi K. Arora, Aleksei Mikhailov, Jinheon Jeong, Seungyeob Kim, Yamin Zhang, Ravi F. Nuxoll, Hak-Young Ahn, Geumbee Lee, Shupeng Li, Dae-Hyeon Song, Sangwon Cha, Young Jin Jo, Sang Min Won, Tae-il Kim, Yei Hwan Jung, Sumanas W. Jordan, Yonggang Huang, Jae-Young Yoo, Igor R. Efimov, Colin K. Franz, Zhenqiang Ma, Sung Hun Jin, John A. Rogers

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Abstract

Wireless bioresorbable systems for electrical stimulation can deliver electrotherapy over clinically relevant timeframes, and then subsequently dissolve away in a harmless fashion. Such systems have previously been used in neuroregeneration and cardiac pacing, delivering monophasic pulses to a targeted site. Here we report a wirelessly powered system with programmable control of the stimulation waveforms using tissue-penetrating near-infrared light. The approach relies on a bioresorbable silicon phototransistor that is designed to optically modulate current flows at critical nodes in electrical circuits. We show that the approach can offer precise control over stimulation pulses—allowing monophasic, biphasic and polyphasic waveforms to be delivered to single or multiple sites—and all with power wirelessly delivered to a single receiver unit. Using small and large animal models, we further show that the technology enables single- and dual-chamber cardiac pacing, as well as phrenic neuromuscular stimulation for inducing and blocking diaphragmatic excursion. Using a bioresorbable silicon phototransistor to optically modulate current flows in electrical circuits, a wirelessly powered stimulation system can be created that offers programmable control over stimulation waveforms with tissue-penetrating near-infrared light.

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一种无线供电、光控、生物可吸收的刺激系统，具有可编程的多相波形

用于电刺激的无线生物可吸收系统可以在临床相关的时间框架内提供电疗，然后以无害的方式溶解。这种系统以前曾用于神经再生和心脏起搏，将单相脉冲传递到目标部位。在这里，我们报告了一种无线供电系统，该系统使用组织穿透近红外光对刺激波形进行可编程控制。该方法依赖于一种生物可吸收的硅光电晶体管，该晶体管被设计用于光调制电路中关键节点的电流。我们的研究表明，这种方法可以精确控制刺激脉冲，允许单相、双相和多相波形传输到单个或多个位置，并且所有的能量都无线传输到单个接收器单元。通过小型和大型动物模型，我们进一步表明，该技术可以实现单室和双室心脏起搏，以及膈神经肌肉刺激，以诱导和阻断膈肌漂移。

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来源期刊

Nature Electronics Engineering-Electrical and Electronic Engineering

CiteScore

47.50

自引率

2.30%

发文量

159

期刊介绍： Nature Electronics is a comprehensive journal that publishes both fundamental and applied research in the field of electronics. It encompasses a wide range of topics, including the study of new phenomena and devices, the design and construction of electronic circuits, and the practical applications of electronics. In addition, the journal explores the commercial and industrial aspects of electronics research. The primary focus of Nature Electronics is on the development of technology and its potential impact on society. The journal incorporates the contributions of scientists, engineers, and industry professionals, offering a platform for their research findings. Moreover, Nature Electronics provides insightful commentary, thorough reviews, and analysis of the key issues that shape the field, as well as the technologies that are reshaping society. Like all journals within the prestigious Nature brand, Nature Electronics upholds the highest standards of quality. It maintains a dedicated team of professional editors and follows a fair and rigorous peer-review process. The journal also ensures impeccable copy-editing and production, enabling swift publication. Additionally, Nature Electronics prides itself on its editorial independence, ensuring unbiased and impartial reporting. In summary, Nature Electronics is a leading journal that publishes cutting-edge research in electronics. With its multidisciplinary approach and commitment to excellence, the journal serves as a valuable resource for scientists, engineers, and industry professionals seeking to stay at the forefront of advancements in the field.