Porcine intestinal goblet cells: Guardians of mucosal immunity and barrier function

IF 8.3 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal Nutrition Pub Date : 2026-05-30 DOI:10.1016/j.aninu.2026.02.003

Chenbin Cui, Jiaxi Tang, Jing Hou, Jianjian Zhang, Min Tian, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang

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Abstract

Goblet cells are a type of secretory cell in the intestinal epithelium, characterized by their continuous production and secretion of mucin. Goblet cell-associated antigen passage (GAP)-mediated antigen presentation offers intestinal tolerance to innocuous luminal antigens and systemic resistance to infection. However, multiple factors can impair goblet cell abundance influencing mucin production in swine. Therefore, strategies aimed at maintaining porcine goblet cell homeostasis could provide an important role in the protection of gut health, ultimately enhancing porcine health and production performance. This review summarizes the current knowledge on porcine goblet cells, including methods of examination, their development and functions, and demonstrations of the presence of GAPs in the porcine small intestine. This review also lists the factors and nutrients that influence goblet cell homeostasis in swine production and discusses the potential roles of porcine goblet cells in nutrient digestion and absorption. Overall, this review highlights the importance of preserving the goblet cell-mediated portion of intestinal homeostasis and advances the understanding of porcine goblet cells, providing opportunities for the development of new methods to improve gut health in swine production.

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猪肠杯状细胞：黏膜免疫和屏障功能的守护者

杯状细胞是肠上皮内的一种分泌细胞，其特点是不断产生和分泌粘蛋白。杯状细胞相关抗原传代（GAP）介导的抗原呈递提供肠道对无害腔内抗原的耐受性和对感染的全身抵抗力。然而，多种因素可损害杯状细胞丰度，影响猪的粘蛋白产生。因此，旨在维持猪杯状细胞稳态的策略可能在保护肠道健康，最终提高猪的健康和生产性能方面发挥重要作用。本文综述了目前关于猪杯状细胞的研究进展，包括检测方法、它们的发育和功能，以及猪小肠中gap存在的证据。本文还列出了影响猪生产中杯状细胞稳态的因素和营养物质，并讨论了猪杯状细胞在营养物质消化和吸收中的潜在作用。总之，这篇综述强调了保存杯状细胞介导的肠道稳态部分的重要性，并推进了对猪杯状细胞的理解，为开发新的方法来改善猪生产中的肠道健康提供了机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animal Nutrition Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

7.40

自引率

3.20%

发文量

172

审稿时长

12 weeks

期刊介绍： Animal Nutrition encompasses the full gamut of animal nutritional sciences and reviews including, but not limited to, fundamental aspects of animal nutrition such as nutritional requirements, metabolic studies, body composition, energetics, immunology, neuroscience, microbiology, genetics and molecular and cell biology related to nutrition, and more applied aspects of animal nutrition, such as raw material evaluation, feed additives, nutritive value of novel ingredients and feed safety.