LncRNA Lncbate1 promotes lipid synthesis in the white adipose tissue during aging by targeting the miR-455-5p-ACSS1 axis.

Abstract

Lipid metabolism is closely related to aging, and its disorders can lead to obesity, insulin resistance, cardiovascular diseases, and various other conditions. The accumulation of lipids caused by increased lipid synthesis is key in the development of obesity, but the molecular mechanisms of increased lipid synthesis remain to be thoroughly studied, especially in the context of aging. In this work, we used in vivo and in vitro models to demonstrate that the long noncoding RNA Lncbate1 contributes to obesity by promoting lipid accumulation. Specifically, Lncbate1 increases lipid synthesis by downregulating the expression of miR-455-5p to increase the expression of the lipid synthesis gene ACSS1. Our findings highlighted Lncbate1 as a likely target for the intervention of aging-related obesity.