Ayana Suzuki, Mitsuyoshi Hirokawa, Hidetaka Yamamoto, Takuya Higashiyama, Takashi Akamizu
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Abstract
Introduction: Herein, we present the first documented case of a solitary fibrous tumor (SFT) arising within thyroid follicular nodular disease and discuss its histogenesis.
Case presentation: A man in his 60s presented with a left thyroid nodule. Histologically, the nodule was composed of spindle cells and thyroid follicles. The spindle cells were positive for CD34 and STAT6, negative for PAX8 and cytokeratin, and harbored a NAB2::STAT6 fusion, confirming the diagnosis of SFT. No extrathyroidal SFT was identified, and the Demicco model classified the tumor as low risk.
Conclusion: This report suggests that SFT may arise de novo within the stromal component of thyroid follicular nodular disease. This underscores the need to consider SFT in the differential diagnosis of spindle-cell lesions occurring within thyroid nodules.
期刊介绍：
''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.
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