The Association between Sarcopenia and Chronic Kidney Disease among the Patients of Diabetes Mellitus: Korean National Health and Nutrition Examination Survey 2008-2011.

Abstract

Background: This study aims to investigate the association between sarcopenia and chronic kidney disease (CKD) among diabetes mellitus (DM) patients.

Methods: The study used the data extracted from 1,855 patients collected by the Korean National Health and Nutrition Examination Surveys conducted in 2008-2011. Body mass index (BMI)-adjusted, weight-adjusted, and height2 -adjusted appendicular skeletal muscle mass were used to define sarcopenia, and the young reference group was analyzed for the cutoff values, which are 0.9 for men 0.6 for women in BMI-adjusted, 29.6 for men, and 23.3 for women in weight-adjusted, and 6.9 - men and 4.8 - women in height2-adjusted index. Participants were classified as having diabetes if they either presented with a fasting plasma glucose ≥126 mg/dL (7.00 mmol/L) or glycated hemoglobin ≥6.5% (48 mmol/moL) or provided any self-report of a physician's diagnosis or current treatment of diabetes. The equation developed by the CKD Epidemiology Collaboration was used to calculate the estimated glomerular filtration rate (eGFR). CKD was defined as having an eGFR less than 60 mL/min/1.73 m2. The association between sarcopenia and CKD was assessed using multiple logistic regression, adjusting for potential confounders.

Results: The final analysis included 1,855 participants with diabetes. After adjusting for potential confounders, sarcopenia was significantly associated with an increased prevalence of CKD. Specifically, patients with sarcopenia had 1.826 times the odds of having CKD compared to those without sarcopenia (odds ratio, 1.826; 95% confidence interval, 1.092-3.054).

Conclusions: There is an association between sarcopenia and CKD in DM patients.