Mohammad H Hussein, Peter P Issa, Tessa R Lavorgna, Chad P Issa, Charlotte Pecot, Manal S Fawzy, Eman A Toraih
{"title":"Adrenal Carcinoma Laterality is of Limited Clinical Significance: A National Perspective.","authors":"Mohammad H Hussein, Peter P Issa, Tessa R Lavorgna, Chad P Issa, Charlotte Pecot, Manal S Fawzy, Eman A Toraih","doi":"10.1080/07357907.2026.2675647","DOIUrl":null,"url":null,"abstract":"<p><p>The clinical implication of adrenal cancer laterality is not well investigated. This retrospective study used the National Cancer Database, including 3962 patients with primary adrenal malignancies. Similar analyses of patients with adrenal cancer were retrieved from the cBioPortal/The Cancer Genome Atlas to validate our findings. Left-sidedness was associated with larger tumor size and distant metastasis, while right-sided tumors displayed LN metastasis more often. There was no difference in survival between the two groups. Analysis of differential genomic and transcriptomic/proteomic effects between right/left adrenal carcinomas was found to be similar. Our analysis highlighted the limited clinical importance of adrenal carcinoma laterality.</p>","PeriodicalId":9463,"journal":{"name":"Cancer Investigation","volume":" ","pages":"863-873"},"PeriodicalIF":2.2000,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/07357907.2026.2675647","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The clinical implication of adrenal cancer laterality is not well investigated. This retrospective study used the National Cancer Database, including 3962 patients with primary adrenal malignancies. Similar analyses of patients with adrenal cancer were retrieved from the cBioPortal/The Cancer Genome Atlas to validate our findings. Left-sidedness was associated with larger tumor size and distant metastasis, while right-sided tumors displayed LN metastasis more often. There was no difference in survival between the two groups. Analysis of differential genomic and transcriptomic/proteomic effects between right/left adrenal carcinomas was found to be similar. Our analysis highlighted the limited clinical importance of adrenal carcinoma laterality.
期刊介绍：
Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.
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