Tuft cells awaken Th2 recall responses.

IF 7.6 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2026-07-01 Epub Date: 2026-06-17 DOI:10.1016/j.pt.2026.06.001

Gasmi Imène, Jay Philippe

引用次数: 0

Abstract

Stanbery et al. show that tuft cells, previously defined as epithelial activators of innate type 2 immunity, are dispensable for memory T helper 2 (Th2) cell establishment but required for protective immunity during secondary helminth infection. This involves tuft cell secretion of interleukin-25 and leukotriene C4 to promote memory Th2 effector function.

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Tuft细胞唤醒Th2回忆反应。

Stanbery等人表明，簇状细胞，以前被定义为先天性2型免疫的上皮激活剂，对于记忆T辅助2 （Th2）细胞的建立是必不可少的，但对于继发性蠕虫感染的保护性免疫是必需的。这涉及到簇状细胞分泌白介素-25和白三烯C4来促进记忆Th2效应的功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.