Retrospective study on diagnostic yield and medical impact of diagnostic imaging in dogs with immune-mediated haemolytic anaemia in Belgium

IF 1.5 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice Pub Date : 2026-10-04 Epub Date: 2026-06-18 DOI:10.1111/jsap.70159

R. Vlassenbroek, D. Peeters, L. Matthewman, C. François, G. Bolen, K. Gommeren

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引用次数: 0

Abstract

Objectives

To assess the incidence of associative immune-mediated haemolytic anaemia in dogs diagnosed with immune-mediated haemolytic anaemia and to evaluate whether performing diagnostic imaging, specifically thoracic radiographs and abdominal ultrasound, influences outcomes in non-associative immune-mediated haemolytic anaemia.

Materials and Methods

Medical records (2017 to 2023) were reviewed for dogs diagnosed with immune-mediated haemolytic anaemia. Dogs were classified as associative immune-mediated haemolytic anaemia or non-associative immune-mediated haemolytic anaemia. Survival odds at 3, 6 and 12 months were assessed for non-associative immune-mediated haemolytic anaemia. Multivariable logistic regression was used to identify factors associated with a risk of decreased survival.

Results

Among 117 immune-mediated haemolytic anaemia cases, 7 (6%) had associative immune-mediated haemolytic anaemia, and 110 (94%) had non-associative immune-mediated haemolytic anaemia. In non-associative immune-mediated haemolytic anaemia dogs, thoracic radiographs were performed in 63 dogs (57.3%) and abdominal ultrasound in 90 dogs (81.8%), with unremarkable thoracic radiographs in 55.5% of cases and unremarkable abdominal ultrasound in 17.8%. Diagnostic imaging did not significantly affect the risk of decreased survival at 3, 6 and 12 months (P > .05). Increasing age (OR [95% CI]: 1.31 [1.06 to 1.61] at 12 months), elevated serum alanine aminotransferase (OR [95% CI]: 3.93 [1.11 to 14.0] at 3 months) and a higher number of packed red blood cell transfusions (OR [95% CI]: 2.10 [1.09 to 4.08] at 3 months and 1.91 [1.02 to 3.56] at 6 months) were associated with an increased risk of decreased survival.

Clinical Significance

Performing diagnostic imaging was not associated with a change in survival odds in dogs with non-associative immune-mediated haemolytic anaemia in this cohort. These findings suggest individual case-based diagnostic imaging may be appropriate in clinical practice.

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比利时犬免疫介导溶血性贫血诊断成像的诊断率和医学影响回顾性研究

目的：评估被诊断为免疫介导溶血性贫血的犬中关联免疫介导溶血性贫血的发生率，并评估影像学诊断，特别是胸片和腹部超声检查是否会影响非关联免疫介导溶血性贫血的预后。材料和方法：回顾了2017年至2023年诊断为免疫介导的溶血性贫血犬的医疗记录。狗被分为联合免疫介导的溶血性贫血和非联合免疫介导的溶血性贫血。评估非关联免疫介导的溶血性贫血患者在3、6和12个月时的生存几率。使用多变量逻辑回归来确定与生存降低风险相关的因素。结果：117例免疫介导的溶血性贫血中，7例（6%）为关联免疫介导的溶血性贫血，110例（94%）为非关联免疫介导的溶血性贫血。在非关联免疫介导的溶血性贫血犬中，63只犬（57.3%）进行了胸片检查，90只犬（81.8%）进行了腹部超声检查，其中55.5%的病例胸片检查不显著，17.8%的病例腹部超声检查不显著。诊断性影像学对3、6、12个月生存率降低的风险无显著影响（P < 0.05）。年龄增加（12个月时OR [95% CI]: 1.31[1.06至1.61]）、3个月时血清丙氨酸转氨酶升高（OR [95% CI]: 3.93[1.11至14.0]）和大量填充红细胞输注（OR [95% CI]: 3个月时2.10[1.09至4.08]，6个月时1.91[1.02至3.56]）与生存降低的风险增加相关。临床意义：在该队列中，进行诊断成像与非关联免疫介导的溶血性贫血犬的生存几率变化无关。这些发现表明，在临床实践中，基于个案的诊断成像可能是合适的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Small Animal Practice 农林科学-兽医学

CiteScore

3.30

自引率

6.20%

发文量

117

审稿时长

12-24 weeks

期刊介绍： Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery. In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world. The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher. The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association