Danilo DO Rosário Pinheiro, Débora Mendes DE Andrade, Nayara Cristina Lima DE Oliveira, Bárbara DO Nascimento Borges
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引用次数: 0
Abstract
Canine mammary cancer (CMC) is the most common cancer in female dogs, especially those that are unspayed, representing a significant health issue in veterinary medicine. It is a tumor with a multifactorial origin, sharing several risk factors with its human counterpart. Molecular alterations play a crucial role in the development of this tumor type. Among these, epigenetic modifications are particularly important because they regulate gene expression without altering the DNA sequence. These modifications influence key cellular processes involved in tumor progression, such as cell motility, invasion, angiogenesis, and chemotherapy resistance. This review focuses on the main epigenetic changes observed in CMCs, and explores their potential in diagnosis and prognosis, including minimally invasive methods.
期刊介绍：
Journal of Reproduction and Development (JRD) is the
official journal of the Society for Reproduction and Development,
published bimonthly, and welcomes original articles. JRD
provides free full-text access of all the published articles on
the web. The functions of the journal are managed by Editorial
Board Members, such as the Editor-in-Chief, Co-Editor-inChief, Managing Editors and Editors. All manuscripts are
peer-reviewed critically by two or more reviewers. Acceptance
is based on scientific content and presentation of the materials.
The Editors select reviewers and correspond with authors. Final
decisions about acceptance or rejection of manuscripts are made
by the Editor-in-Chief and Co-Editor-in-Chief.
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