Differential associations of lipid profile and genetic susceptibility with sleep duration.

IF 6.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2026-06-16 DOI:10.1186/s12944-026-02998-z

Zihao Zhang, Yuanyuan Zhang, Ziyi Peng, Yirong Yang, Kuan Ning, Yijia Chen, Yuhe Wu, Xuerui Yao, Hailun Wu, Yifan Wang, Hancun Yi, Dandan Tan, Tanxiu Chen, Daojun Hong, Wen-Quan Zou

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引用次数: 0

Abstract

Background: Lipid metabolism is influenced by multiple factors, and its association with sleep duration may vary across lipid fractions. Lipid levels and their genetic susceptibility have been associated with sleep duration; however, these associations are heterogeneous, and it remains unclear whether specific lipid components exhibit more consistent associations with sleep duration.

Methods: This study included 410,493 participants from the UK Biobank. Multivariable linear regression (MLR) was used to assess the associations of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) with sleep duration. Polygenic risk scores (PRSs) were incorporated to evaluate genetic susceptibility. Interaction terms between lipid levels and PRSs were included in multivariable models. Cox proportional hazards models were used to examine the associations of lipid levels and PRSs with sleep disorders. Joint exposure analyses of lipid levels and PRSs were performed, and interaction effects were assessed. Restricted cubic spline models were further applied to evaluate potential non-linear associations. Proteomic analyses were conducted to explore proteomic features associated with both lipid profile and sleep duration.

Results: MLR analyses showed that TG levels were positively associated with sleep duration (β = 0.027, P < 0.001), whereas TC levels were inversely associated with sleep duration (β = -0.005, P = 0.005). No significant association was observed for LDL. In contrast, PRSs for TG, TC, and LDL were consistently inversely associated with sleep duration. A significant interaction was observed between TG and their PRS (β = -0.009, p < 0.001). TG and PRS-TG were associated with higher risks of sleep disorders (6.9% and 3.2% per unit increase), with a significant interaction (p = 0.014). Elevated risks were observed in high TG groups, while TC and LDL were not significant. Both lipid traits and sleep duration were mainly enriched in immune and inflammatory pathways.

Conclusions: Triglycerides showed the most consistent associations with sleep duration, and TG-related genetic susceptibility may influence TG levels and their associations with sleep duration and sleep disorders.

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脂质特征和遗传易感性与睡眠时间的差异关联。

背景：脂质代谢受多种因素影响，其与睡眠时间的关系可能因脂质组分而异。脂质水平及其遗传易感性与睡眠时间有关；然而，这些关联是异质的，目前尚不清楚特定的脂质成分是否与睡眠时间有更一致的关联。方法：本研究包括来自英国生物银行的410,493名参与者。采用多变量线性回归（MLR）评估甘油三酯（TG）、总胆固醇（TC）和低密度脂蛋白（LDL）与睡眠时间的关系。采用多基因风险评分（PRSs）评价遗传易感性。脂质水平与prs之间的相互作用项被纳入多变量模型。Cox比例风险模型用于检查脂质水平和PRSs与睡眠障碍的关系。进行了脂质水平和PRSs的联合暴露分析，并评估了相互作用的影响。限制三次样条模型进一步应用于评估潜在的非线性关联。进行蛋白质组学分析以探索与脂质谱和睡眠时间相关的蛋白质组学特征。结果：MLR分析显示TG水平与睡眠持续时间呈正相关（β = 0.027， P）。结论：甘油三酯与睡眠持续时间的关系最为一致，TG相关的遗传易感性可能影响TG水平及其与睡眠持续时间和睡眠障碍的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.