Clinical Outcomes of Patients Bilaterally Implanted with the Light Adjustable Lens: Results of a Phase IV Clinical Registry.

IF 3.7 3区医学 Q2 OPHTHALMOLOGY

Journal of cataract and refractive surgery Pub Date : 2026-06-16 DOI:10.1097/j.jcrs.0000000000001994

Julie M Schallhorn, Alekya Rajanala

{"title":"Clinical Outcomes of Patients Bilaterally Implanted with the Light Adjustable Lens: Results of a Phase IV Clinical Registry.","authors":"Julie M Schallhorn, Alekya Rajanala","doi":"10.1097/j.jcrs.0000000000001994","DOIUrl":null,"url":null,"abstract":"Purpose: To report the outcomes of the Light Adjustable Lens (LAL) collected from a clinical registry.Setting: Multiple private practices in the United States.Design: Multi-center prospective observational study.Methods: Patients who underwent bilateral LAL implantation and who had best-corrected distance visual acuity (CDVA) ≥ 20/20-2 before lens adjustment were enrolled. Assessment was performed at one visit 1-3 months after final lock-in treatment.Results: A total of 1101 participants (2202 eyes) were included. Of these, 586 eyes had prior corneal refractive surgery (CRS) and 1616 had no prior CRS (No CRS). 12.3% of participants were targeted for bilateral emmetropia, 9.3% for bilateral near and 78.4% for blended vision. Of eyes targeted for emmetropia, 81.2% achieved a UDVA of >20/20 (82.2% of No CRS and 78.4% of CRS). A total of 94.3% of eyes targeted for emmetropia had a MSE of <0.5D (94.7% of No CRS, 92.8% of CRS). The mean prediction error in MSE was -0.048 ± 0.366D in No CRS and -0.016 ± 0.441D in CRS. A total of 89% of patients with blended vision and 93% of patients with bilateral emmetropic target had binocular UCVA of >20/20. In the CRS, group 87% with blended vision and 87% with binocular emmetropia achieved binocular UCVA of >20/20. Binocular UNVA of >J1 was achieved with blended vision in 85% of patients in the No CRS group and 82% of patients in the CRS group.Conclusions: In this multi-center study, patients achieved a high degree of precision with the LAL regardless of prior corneal refractive surgery.","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cataract and refractive surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/j.jcrs.0000000000001994","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To report the outcomes of the Light Adjustable Lens (LAL) collected from a clinical registry.

Setting: Multiple private practices in the United States.

Design: Multi-center prospective observational study.

Methods: Patients who underwent bilateral LAL implantation and who had best-corrected distance visual acuity (CDVA) ≥ 20/20-2 before lens adjustment were enrolled. Assessment was performed at one visit 1-3 months after final lock-in treatment.

Results: A total of 1101 participants (2202 eyes) were included. Of these, 586 eyes had prior corneal refractive surgery (CRS) and 1616 had no prior CRS (No CRS). 12.3% of participants were targeted for bilateral emmetropia, 9.3% for bilateral near and 78.4% for blended vision. Of eyes targeted for emmetropia, 81.2% achieved a UDVA of >20/20 (82.2% of No CRS and 78.4% of CRS). A total of 94.3% of eyes targeted for emmetropia had a MSE of <0.5D (94.7% of No CRS, 92.8% of CRS). The mean prediction error in MSE was -0.048 ± 0.366D in No CRS and -0.016 ± 0.441D in CRS. A total of 89% of patients with blended vision and 93% of patients with bilateral emmetropic target had binocular UCVA of >20/20. In the CRS, group 87% with blended vision and 87% with binocular emmetropia achieved binocular UCVA of >20/20. Binocular UNVA of >J1 was achieved with blended vision in 85% of patients in the No CRS group and 82% of patients in the CRS group.

Conclusions: In this multi-center study, patients achieved a high degree of precision with the LAL regardless of prior corneal refractive surgery.

查看原文本刊更多论文

双侧植入可调光晶状体患者的临床结果：一项IV期临床登记的结果。

目的：报告从临床登记中收集的光可调晶状体（LAL）的结果。背景：在美国拥有多家私人诊所。设计：多中心前瞻性观察研究。方法：纳入晶状体调整前最佳矫正距离视力(CDVA)≥20/20-2的双侧LAL植入术患者。在最终锁定治疗后1-3个月进行一次访问评估。结果：共纳入1101名受试者（2202只眼）。其中，586只眼睛有过角膜屈光手术（CRS）， 1616只眼睛没有角膜屈光手术（no CRS）。12.3%的参与者为双侧远视，9.3%为双侧近视，78.4%为混合视力。在治疗斜视的患者中，81.2%的患者UDVA达到了20/20（无CRS患者占82.2%，CRS患者占78.4%）。94.3%的斜视靶眼的MSE为20/20。在CRS中，87%的混合性视力组和87%的双眼斜视组双眼UCVA达到了bbb20 /20。无CRS组85%的患者和CRS组82%的患者在混合视力下实现了>J1的双眼UNVA。结论：在这项多中心研究中，无论患者是否进行过角膜屈光手术，LAL都获得了高度的精确度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

$Journal of cataract and refractive surgery$

Journal of cataract and refractive surgery 医学-外科

CiteScore

5.60

自引率

14.30%

发文量

259

审稿时长

8.5 weeks

期刊介绍： The Journal of Cataract & Refractive Surgery (JCRS), a preeminent peer-reviewed monthly ophthalmology publication, is the official journal of the American Society of Cataract and Refractive Surgery (ASCRS) and the European Society of Cataract and Refractive Surgeons (ESCRS). JCRS publishes high quality articles on all aspects of anterior segment surgery. In addition to original clinical studies, the journal features a consultation section, practical techniques, important cases, and reviews as well as basic science articles.