Reduction in Respiratory Syncytial Virus (RSV)-Related Outpatient and Inpatient Cases Among Infants During the Initial 2024/2025 Season Following Nirsevimab Recommendation in Germany

IF 3.9 4区医学 Q1 INFECTIOUS DISEASES

Influenza and Other Respiratory Viruses Pub Date : 2026-06-17 DOI:10.1111/irv.70274

Wei Cai, Isabelle Maronde, Sophie Köndgen, Barbara Biere, Silke Buda, Brunhilde Schweiger, Doreen Staat, Walter Haas, Ekkehard Schuler, Virologic SARI Surveillance Study Group, Thorsten Wolff, Ralf Dürrwald, Djin-Ye Oh, Kristin Tolksdorf, Janine Reiche

引用次数: 0

Abstract

After introducing nirsevimab during the 2024/2025 respiratory syncytial virus (RSV) season in Germany, RSV activity in infants under 1 year dropped by 50% in primary care and 50%–70% in secondary care. Inpatients under 6 months showed the greatest reduction. RSV severity decreased with fewer RSV-associated ICU admissions and shorter hospital stays. RSV sequence analysis identified four known polymorphisms in the nirsevimab binding site among inpatients; none associated with resistance. These findings indicate that nirsevimab effectively reduced medically attended RSV disease in infants.

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在德国Nirsevimab推荐后，在最初的2024/2025季节期间，婴儿中与呼吸道合胞病毒（RSV）相关的门诊和住院病例减少

在德国于2024/2025呼吸道合胞病毒（RSV）流行季节引入nirseimab后，1岁以下婴儿的RSV活性在初级保健中下降了50%，在二级保健中下降了50%-70%。住院6个月以下的患者降幅最大。RSV严重程度随RSV相关ICU入院人数减少和住院时间缩短而降低。RSV序列分析在住院患者中发现了4个已知的nirseimab结合位点多态性；与抵抗无关。这些发现表明，尼瑟维单抗有效地减少了婴儿的呼吸道合胞病毒疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Influenza and Other Respiratory Viruses 医学-病毒学

CiteScore

7.20

自引率

4.50%

发文量

120

审稿时长

6-12 weeks

期刊介绍： Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.